When one analyzes people living to a ripe old age in reasonable health without the need of supplementation, one finds that they had a lot of odds in their favor. It usually starts with excellent genes, followed by a lack of factors that tend to upset the biochemical balance necessary to maintain good health. Anything upsetting that cellular nutrition balance will either shorten someone's life, worsen its quality, or require compensation through extra nutritional support or drug intervention. A centenarian who never touched a supplement in his life has likely maintained such a balance as a result of little pro-oxidant activity, which necessitated little antioxidant activity, just to mention one example. On the other hand, let's assume a very healthy individual with similar longevity odds in his favor ends up with a serious trauma early in life. The imbalance introduced to his previously sound chemistry by drug treatments or organ damage will have him for the rest of his life search for compensatory factors to improve the quality of life. Unlike before his injury, he is now in the same situation as those born less fortunate health-wise, and may now have to become more reliant on better nutrition and or additional supplementation. So the reason for supplementation, and the dosages required, can change with individual circumstances. The difference between individuals who take nutritional supplements, and those who do not, can perhaps be compared to younger versus older people facing the same medical crisis. Younger people simply tend to handle various medical situations better, or recover faster than older ones, so the right nutritional supplementation may perhaps be compared to lowering someone's biological age... Full Text