Higher acid levels in the upper portion of the stomach support iron uptake, but result in calcium loss, while high acid levels in the lower portion of the stomach support manganese uptake, but result in magnesium loss. This effect is generally negligible unless there is a significant Ca Mn or Fe Mg ratio conflict, or acid-lowering drugs such as Proton Pump Inhibitors are used, which will raise magnesium, following a reduction of acid in the lower portion of the stomach. However the effect of these drugs on liver functions will result in excessive manganese levels... Full Text