Hesperidin supplemental requirements are proportional to an individual's copper levels. Since copper is a potent hesperidin antagonist, hesperidin requirements can range from a low of 10mg - 25mg with normal copper levels, to a high of 300mg - 500mg with moderate to higher copper levels. With ongoing excessive copper intake, one cannot normalize hesperidin levels any longer, no matter how much is supplemented. The same does not apply to Rutin, since chromium levels are rarely high enough to inhibit rutin uptake... Full Text