Of course, someone's chemical profile is unlikely to be perfect before starting on B-Complex vitamins, so it will vary from one individual to the next, and when other supplements are added. However, the inhibiting effect of an equalized B-Vitamin complex on iron and manganese, will in people predisposed to iron-deficiency anemia, and or reactive hypoglycemia cause a pronounced worsening of their symptoms. Perhaps this tiring effect was at some point erroneously interpreted as having a stress-reducing effect, hence the subsequent Stress Tab designation... Full Text