Larger doses of Vitamin B6 will also result in a high Magnesium low Calcium Ratio, so if not matched to a patient's requirements, a severe calcium deficiency develops. This by itself - or when aggravated by an overstimulated thyroid from the regular Vitamin B6 B12 shots - can result in insomnia, anxieties, mood swings, chest pains, depression, joint pains, muscle cramps, or other symptoms... Full Text