Nickel Toxicity is usually not a problem unless several grams are ingested from non-dietary sources, or unless there is a natural tendency to retain too much nickel, which could lead to asthma, angina an or other cardiac symptoms as a result of nickel interfering with Vitamin E activity. However, nickel is quite toxic in its gaseous form of nickel carbonyl, and it has the potential to cause cancer of the sinuses, throat and lungs when insoluble nickel compounds are inhaled for long periods of time. This does not apply to soluble nickel compounds such as chloride, nitrate, or sulfate... Full Text