Nickel is a trace element that has been linked to skin allergies or dermatitis in regard to eyeglass frames, dental materials, and costume jewelry, however of the approximately 10 mg in the body, significant amounts of nickel are found in RNA and DNA where it interacts with these nucleic acids. Most of plasma nickel is a constituent of the circulating proteins nickeloplasmin and albumin, and it is also thought to be a factor in hormone, lipid and cell membrane metabolism. Insulin response is increased after ingesting nickel, which may be related to its activation of enzymes associated with the breakdown or utilization of glucose... Full Text