The trials Dr. Ronald Roth had run with boron showed that it increases calcium & magnesium retention, but at the expense of lowering manganese, which is one of the co-factors that helps calcium uptake. So realistically, the only circumstances which would justify the use of boron for osteoporosis - or any other condition - are situations where patients suffer from congestive liver disease, resulting in high manganese levels, which would subsequently cause calcium depletion... Full Text