A number of hormones, including thyroid, parathyroid, sex hormones, Vitamin D3, and others exert their effect on bone remodeling and interact with immune system proteins such a interleukin-6. Their production in turn is inhibited by estrogen and testosterone, so there is evidence that the balance of sex hormones and interleukin-6 influences trabecular bone loss. Research also implicates the same mechanism as a potential cause of some forms of hyperthyroidism, hyperparathyroidism, rheumatoid arthritis, multiple myeloma, Paget's disease, and others... Full Text