One can easily see negative, rather than positive effects arising when randomly supplementing high doses of single, instead of complexed vitamins, particularly in the absence of deficiencies. For practical purposes however, the best way to reduce the risk of cardiovascular disease is to raise one's Vitamin C intake proportionately to the amounts of Vitamin E consumed, which - by maintaining a normal Vitamin C Vitamin E ratio - will generally prevent any potential negative consequences. At the same time, when various scientific studies come to totally opposite conclusions, particularly concerning nutritional supplementation, both sides should be taken with a grain of salt, since agendas may have played heavily into their outcomes... Full Text