However when doses multiple times the recommended daily intake are supplemented, B-Vitamins - like other nutrients - produce stronger therapeutic effects that can vary considerably from one individual to another. Subsequently, depending on age, genetic background, and preexisting medical conditions that impact the body's ability to cope with 50 mg, 75 mg, and 100 mg B-Complex formulations, negative results can easily outweigh the benefits that B-vitamins would otherwise provide when supplemented at much lower amounts... Full Text