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Dr. Ronald Roth Acu-Cell AI

Selenium Transport via Selenoprotein P (SELENOP)

  • Primary role: Selenoprotein P is the major transport protein responsible for distributing selenium from the liver to extrahepatic tissues via the blood plasma.
  • Proportion: It accounts for approximately 50% or more of the total selenium circulating in human blood plasma.
  • Functional capacity: Unlike other selenoproteins that primarily contain selenium for their own enzymatic activity, SELENOP contains multiple selenium atoms (specifically as selenocysteine residues) explicitly designated for transport and delivery purposes.
  • Receptor-mediated uptake: Target tissues take up selenium from plasma SELENOP through specific cell-surface receptors, primarily megalin (LRP2) and LRP8 (apolipoprotein E receptor 2), ensuring that vital organs like the brain and testes receive adequate selenium supply even during states of dietary deficiency.
AI-generated in the approach of Dr. Ronald Roth. Not his own words.
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Connections

Substance P - connections

Substance P ->

Selenium - connections

Selenium ->

-> Selenium

Plasma estradiol - connections

-> Plasma estradiol

  • Boron - Raises (Attribution: some researchers)
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