HealthMap

Calcium supplementation - connections

Calcium supplementation ->

• Achieves: Calcium absorption (Range: 30-40%; Independence: regardless of solubility; Scope: most types)
• Increases: Calcium absorption (Dose: 300-500 mg; Frequency: throughout the day; Condition: as needed; Population: unable to absorb 1,000+ mg in one meal)
• Increases Risk Of: Cardiovascular disease (Certainty: might; Year: 2012; Claimant: New Zealand researchers)
• Is Timed For: Sleep (Dose: largest single dose of the day; Time: evening; Reason: calcium requirements greatest during sleep)
• Prompts Update To: Physician guidelines (Year: 2012)
• Worsens: Low stomach acid (Amount: large; Condition: without proper analysis)

-> Calcium supplementation

• Physician guidelines - Discourages (Amount: extra)
• Chelated Calcium - Requires Less (Amount: least; Purpose: meet patient requirements)
• New Zealand researchers - Studied (Year: 2012)

Calcium - connections

Calcium ->

• Activates: Fibrin
• Affects: Insulin/glucose metabolism, Muscle contraction
• Antagonizes: Alcohol, Bismuth, Caffeine, Chloride, Chromium, Germanium, Insoluble fiber, Iron, Lecithin, Manganese, Mineral oil, Niacin / niacinamide, Omega-3, Oxalic acid, PABA, Phytic acid, Protein, Sulfur, Vitamin A, Vitamin C, Vitamin E, Zinc
• Antagonizes: Magnesium, Phosphorus (Condition: higher levels; Dependency: dose)
• Antagonizes: Germanium (Degree: most potent; Condition: close to normal levels)
• Antagonizes: Zinc (Degree: very potent)
• Associated With: Hypothermia (Intake: high; Duration: long-term)
• Associated With: Anemia, Aneurysms, Anxiety, Apathy, Arrhythmia, Arteriosclerosis, Arthritis, Calcification, Cardiovascular disease, Cardiovascular disease with artery-wall damage, Cardiovascular disease with coronary artery blockage, Carpal tunnel syndrome, Cataracts, Cold hands and feet, Constipation, Depression, Dermatitis, Dry skin, Fatigue, Glaucoma, Glucose intolerance, Hemorrhoids, High blood pressure, Immune system dysfunctions, Ischemic heart disease, Joint / bone pain, Kidney stones, Menopausal flushing, Moodiness, Muscle / joint pain, Nausea, Osteoarthritis, Osteoporosis, Retinitis pigmentosa, Soft-tissue calcification, Strokes, Triglycerides, Vision impairment (Level: high)
• Associated With: Cancers (Level: high; Cancers: breast, stomach, lung, prostate, pancreatic)
• Associated With: Nails (Level: high; Condition: brittle)
• Associated With: Angina (Level: high; Condition: low_cofactors)
• Associated With: Stomach acid production (Level: high; Modality: may; Location: respective stomach part)
• Associated With: Stomach acid (Level: high; Target level: low)
• Associated With: Blood pressure (Level: high; Target state: high)
• Associated With: Stomach acid (Level: high; Target state: low)
• Associated With: Aneurysms, Anxiety, Arrhythmia, Arthritis, Bedwetting, Birth defects, Bruising, Cardiovascular disease, Cardiovascular disease with artery-wall damage, Carpal tunnel syndrome, Cold hands and feet, Congestive heart failure, Conjunctivitis, Crohn's disease or colitis, Depression, Diarrhea, Dysmenorrhea, Fatigue, Gastritis, Gingivitis, Glucose intolerance, Graying hair, Hemorrhagic stroke, High blood pressure, Hives, Hyperactivity, Immune system dysfunctions, Infertility, Insomnia, Joint / bone pain, Kidney stones, Learning disability, Low sperm count, Menstrual cramps, Miscarriages, Moodiness, Muscle / joint pain, Muscle spasms / cramps, Nausea, Nervousness, Nose bleeds, Osteoporosis, PMS, Palpitations, Periodontal disease, Restlessness, Rickets, Seizures, Slow or impaired growth, Tinnitus ... (Level: low)
• Associated With: Cancers (Level: low; Cancers: colon, left ovarian, left testicular, prostate; Ratio: high zinc/calcium)
• Associated With: Nails (Level: low; Condition: brittle)
• Associated With: Insomnia (Level: low; Measure: level_or_ratio)
• Associated With: Stomach acid (Level: low; Target level: high)
• Associated With: Blood pressure, Stomach acid (Level: low; Target state: high)
• Associated With: Eclampsia or pre-eclampsia, Preeclampsia / Eclampsia (Level: low; Timing: pregnancy)
• Associates With: Magnesium
• Associates With: Colon cancer (Level: insufficient; Frequency: often; Partners: insufficient cellular copper and potassium)
• Causes: Osteoporosis (Certainty: can; Level: high)
• Causes: Osteoporosis (Certainty: can; Level: low)
• Causes: Degenerative effect (Condition: elevated)
• Causes: Excessive blood-thinning (Intake: low; Includes: low_calcium_magnesium_ratio)
• Causes: Arteriosclerosis (Level: high; Modal: can)
• Causes: Degenerative arthritis (Level: high; Modal: may)
• Causes: Arteriosclerosis (Level: high; Modality: can)
• Causes: Arthritis (Level: high; Type: degenerative; Mechanism: calcification; Modality: may)
• Causes: Weight loss (Level: low)
• Causes: health problems (Polarity: negative; Amount: too much; Certainty: never; Claimant: Dr. Takuo Fujita)
• Causes: Brittle nails (Ratio: low; Feature: vertical ridges)
• Causes: Anxiety (State: deficient)
• Causes: Osteopenia (State: deficient; Certainty: can)
• Causes: Osteoporosis (State: deficient; Certainty: can; Timing: eventually)
• Causes: Daytime fatigue (State: deficient; Degree: increased)
• Causes: Horizontal nail ridges (State: deficient; Duration: prolonged; Severity: severe; Progression: increasing; Appearance: groove-like)
• Causes: Sleep disturbances (State: deficient; Forms: light restless sleep or insomnia)
• Causes: Leg cramps (State: deficient; Location: left-sided; Exception: unless magnesium is also low)
• Causes: Joint pains (State: deficient; Location: more often left-sided)
• Contributes To: Ankylosing spondylitis (Level: very high; Aspect: degenerative nature)
• Decreases: Stomach acid (Contrast: exact opposite)
• Decreases: Calcium bioavailability (Level: high; Modal: can)
• Depresses: Cardiac function, Thyroid functions (Degree: not_too_much; Dosage effect: calming)
• Exhibits: Atherogenic properties (Amount: higher)
• Exhibits: Anti-inflammatory properties, Degenerative properties (Level: higher)
• Forms: oyster shell supplement (Temperature: about 800°C; Environment: vacuum)
• Harms: Cardiovascular system (Amount: high; Purpose: osteoporosis prevention; Certainty: can)
• Has Property: Anti-inflammatory properties
• Has Ratio To: Phosphorus (Location: bone; Ratio: 2.5:1)
• Heated In: vacuum (Temperature: about 800°C)
• Impairs: Deep sleep (Level: low; Degree: more difficult; Sleep levels: 3 to 4)
• Improves: Stress-coping ability (Combination: vitamin_d; Dosage effect: calming)
• Increases: Calcium absorption (Amount: 500_mg_or_less; Frequency: throughout_day)
• Increases: Cardiovascular disease, Joint disorders, Osteoporosis (Amount: extra; Population: excessive_calcium_retainers; Aspect: risk)
• Increases: Alkalinity, VLDL triglycerides (Level: elevated)
• Increases: Cancers (Level: high; Condition: low_vitamin_d; Aspect: risk)
• Increases: VLDL triglyceride fraction (Modal: can; Intake: greater; Retention: greater)
• Increases: Cellular magnesium (Timing: over time; Condition: continued supplementation; Exception: potassium high)
• Increases: Calcium absorption (Timing: with_meals)
• Increases Risk Of: Cancers (Level: high; Degree: higher; Scope: several)
• Increases Risk Of: Colorectal cancer (Level: insufficient; Location: cellular; Modality: more likely)
• Increases Risk Of: Cancers (Level: low; Degree: higher; Scope: some)
• Increases Sensitivity To: Atherogenic diets (Transition: raised from below-normal; Diet factors: sugar and trans fat)
• Inhibits: Strontium absorption
• Inhibits: Germanium absorption (Level: excessively high; Progression: progressively; Limit: supplementation no longer increases germanium)
• Inhibits: Vitamin D (Level: high)
• Inhibits: Vitamin D (Level: high; Target level: low)
• Inhibits: Cancer-protective effect (Level: high; Unless: extra vitamin D is supplemented)
• Interacts With: Headaches (Level: too high or too low)
• Interferes With: Healing process (Condition: high levels; Degree: altogether; Modality: can; Context: fracture)
• Interferes With: Vitamin D (Level: high)
• Involved In: Musculoskeletal disorders (Scope: various)
• Is A: Muscle-relaxant nutritional remedies (Importance: most important)
• Is Associated With: Magnesium
• Is Associated With: Arthritic degeneration, Chronic fatigue, Depressive disorders, Gastrointestinal disturbances, High blood pressure, Joint degeneration, Mood disorders, Soft-tissue calcification, Strokes, Vascular degeneration (Level: elevated)
• Is Associated With: Mineral imbalances (Level: elevated; Scope: general)
• Is Associated With: Anxiety (Level: low; Frequency: oftentimes)
• Is Associated With: Depression (Source state: high)
• Is Associated With: Depression (Source state: low)
• Is Cofactor For: Enzymes (Quantity: a number of)
• Is Essential To: Human health
• Is Found In: Teeth (Proportion: 1%; Population: average 70 kg adult)
• Is Found In: Bone (Proportion: almost 98%; Population: average 70 kg adult)
• Is Found In: Blood, Cells, Extracellular fluid (Proportion: part of remainder)
• Is Related To: Depression (Certainty: can; Level: high)
• Is Related To: Depression (Certainty: can; Level: low)
• Lowers: Phosphorus
• Lowers: Acid levels (Amount: high)
• Lowers: Stomach acid (Level: elevated; Frequency: common)
• Negates Effects Of: Stomach acid (Degree: somewhat; Level: abnormally_high_or_low; Condition: with_meals_and_small_doses)
• Opposes: Magnesium (Location: intracellular; Certainty: claimed; Attribution: some sources)
• Overcomes: Calcium deficiency (Amount: larger)
• Prevents: Osteopenia, Osteoporosis (Combination: Vitamin D; Intent: attempted; Amount: extra)
• Promotes: Blood clotting (Mechanism: fibrin activation)
• Raises: Long-chain triglycerides, Medium-chain triglycerides, Phosphorus, Short-chain triglycerides, Total triglycerides, VLDL triglycerides
• Recommended For: Adults (Scope: all individuals)
• Reduces: Inflammation
• Reduces: Side effects (Amount: adequate; Timing: at the same time; Certainty: could)
• Reduces: Stomach acid (Amount: too much; Context: supplementation)
• Reduces: Inflammatory conditions (Degree: significant)
• Reduces: Iron level (Level: excessive)
• Reduces: Iron uptake (Level: high)
• Reduces: Fluoride bioavailability (Level: high; Location: water)
• Reduces: Manganese (Selection: patient match)
• Reduces: Phosphorus (State: elevated)
• Reduces: Total triglycerides (State: high; Exception context: low zinc association)
• Reduces Absorption Of: Zinc in food (Amount: high; Timing: concurrent)
• Regulates: Heartbeat, Muscle contraction, Muscle tone, Nerve conduction (Together with: magnesium)
• Requires For: Normal blood clotting
• Resolves: Muscle spasms and cramps (Dose: 500 mg daily; Timing: quickly; Effect: symptomatic_only; Location: quadriceps; Context: exercise bike)
• Slows: Healing process (Condition: high levels; Modality: can; Context: fracture)
• Slows: Fracture union (Level: high)
• Split Between: Late-day meal, Mid-day meal (Condition: amounts exceed 500 mg; Distribution: equal)
• Supports: Bacterial infections, Viral infections (Intake: adequate; Importance: important; Timing: when fighting)
• Synergizes With: Boron, CoQ10, Copper, Potassium, Saturated fats, Sodium, Strontium, Titanium, Vitamin B5, Vitamin D, Vitamin K
• Synergizes With: Magnesium (Condition: normal levels; Dependency: dose)
• Treats: Osteopenia, Osteoporosis (Combination: Vitamin D; Intent: attempted; Amount: extra)
• Treats: Muscle spasms and cramps (Dose: 300-500 mg; Frequency: two_to_three_times_daily; Duration: couple_of_days; Condition: cellular measurement unavailable; Certainty: trial)
• Treats: Muscle spasms and cramps (Effectiveness: effective; Context: nocturnal; Frequency: many; Timing: during sleep; Modal: can)
• Treats: Cluster headache (Intake: high; Pattern: low-calcium high-phosphorus high-cobalt)
• Treats: Bismuth overdose (Modality: can)
• Triggers: Inflammatory arthritis (Level: low; Modal: may)
• Triggers: Arthritis (Level: low; Type: inflammatory; Modality: may)
• Weakens: Blood vessels (Level: low; Effect: fragile; Modality: may)
• Weakens: Blood vessels (Level: low; Modal: may; State: weak_or_fragile)
• Worsens: Muscle spasms and cramps (Condition: extra supplementation; Modal: if)

-> Calcium

• Stomach acid - Affects
• Sulfur, Vitamin D - Antagonizes
• Magnesium - Antagonizes (Condition: higher levels; Dependency: dose)
• Cluster headache - Associated With (Level: very low; Pattern: other side-dependent chemistry; Frequency: generally)
• Ankylosing spondylitis - Associates With (Level: very high)
• Copper - Associates With (Source level: low; Target level: low; Frequency: frequently)
• Germanium - Benefits (Condition: germanium below normal; Level: very high; Degree: most)
• Oxalic acid - Binds
• Phytic acid - Binds (Condition: bread made from unleavened flour)
• Vitamin B5 - Boosts (Certainty: can; Condition: chronically low calcium absorption)
• Vitamin C - Causes Deficiency Of (Amount: excessive_or_overdose; Certainty: potential; Timing: eventual; Susceptibility: prone)
• Magnesium - Causes Storage (Intake: low; Outcome: high; Certainty: claimed; Attribution: some sources)
• Phosphorus - Combines With (Claimant: Dr. Takuo Fujita)
• Calcium carbonate - Contains
• Milk - Contains (Commonality: very common)
• Vitamin B6 - Decreases (Frequency: regular; Route: injection; Speed: quickly; Level: low)
• Intracellular potassium - Depends On (Interaction: interactive)
• Vitamin C - Deplete (Dose: very high; Condition: not needed; Timing: eventually; Location: bone stores; Outcome: deficiency)
• Excessive zinc intake - Disrupts Balance Of (Timing: eventually)
• Osteocalcin - Excludes From (Location: soft_tissue)
• Phosphorus - Has Ratio To (Scope: dietary; Ratio: 1:1; Quality: ideal; Certainty: estimated)
• Strontium - Has Related Action To (Degree: closely)
• Low stomach acid - Impairs Utilization Of (Frequency: frequently; Quality: proper)
• Vitamin C - Increases (Amount: right; Aspect: bioavailability)
• Boron - Increases (Aspect: retention; Evidence: Dr. Ronald Roth's trials)
• Lecithin, Vitamin A, Vitamin C, Zinc - Increases Requirement For (Intake: excessive; Modal: may)
• Protein - Increases Requirement For (Intake: very_high; Modal: may)
• Vitamin E - Increases Requirement For (Level: high)
• Phosphate - Increases Requirement For (Level: high; Modal: may)
• Calcium loss, Hormonal diseases, Nutritional imbalances - Increases Requirement For (Modal: may)
• Left side - Indicates (Frequency: generally; Requirement: extra)
• One-sided leg cramps - Indicates (Side: left; Frequency: generally; Requirement: extra; Condition: mineral deficiency)
• Manganese, Nickel, Phosphorus - Inhibits
• Germanium - Inhibits (Mechanism: blood thinning)
• Insufficient nutrient intake - Involves (State: insufficient)
• Osteocalcin - Keeps Out Of (Location: soft tissue)
• Caffeine - Leaches From (Amount: excess; Location: bone)
• Phytic acid - Leaches From (Location: bone)
• Medications - Leaches From (Quantity: many; Location: bone)
• High-protein/phosphate sources - Lowers
• Vitamin C - Lowers (Dose: higher; Certainty: possibly; Degree: too much)
• Vitamin C - Lowers (Dose: large; Degree: significantly; Exception: calcium initially high)
• High stomach acid - Lowers (Duration: long-term; Degree: enough to cause chronic insomnia or impaired deep sleep)
• Vitamin C - Lowers (Intake: excessive; Location: cellular; Outcome: deficient)
• Manganese - Lowers (Level: elevated; Condition: some_liver_diseases)
• Germanium - Lowers (Polarity: negative; Condition: calcium excessively high; Timing: after absorption inhibition)
• Osteocalcin - Maintains In (Location: bone)
• Acu-Cell Analysis - Measures (Level: high; Subject: patient case)
• Phosphorus - Metabolically Linked To
• Antibiotics - Normalizes (Subject: patient case; Timing: following treatment)
• Magnesium - Opposes (Location: intracellular; Certainty: claimed; Attribution: some sources)
• Aspirin, NSAIDs - Reduces (Duration: long_term; Timing: eventually; Tendency: true)
• Vitamin E - Reduces (Intake: excessive; Duration: long; Degree: significantly)
• Vitamin B3/4 - Reduces (Level: high)
• Vitamin B6 - Reduces (Level: high; Target state: deficient)
• High-oxalic-acid foods - Reduces (Population: difficulty_maintaining_adequate_calcium; Degree: very_negative)
• Calcitonin - Reduces Availability Of (Source location: bone; Condition: blood calcium rises; Cause: excess parathyroid activity)
• Vitamin K2 - Regulates (Mechanism: gamma_carboxyglutamic_acid_and_osteocalcin)
• Strontium - Related To (Degree: closely; Aspect: action)
• calcium-to-magnesium ratio - Relates
• Calcium-to-magnesium intake ratio - Relates (Value: 2; Variability: changes significantly under individual circumstances)
• Vitamin D - Removes From (Origin: bone; Condition: insufficient_dietary_intestinal_calcium)
• Impaired kidney functions - Requires (Amount: variable; Dependence: health factors, age, medications)
• Magnesium overload - Requires Supplementation (Amount: larger; Scope: some people)
• Stomach acid-lowering medications - Retains (Certainty: likely; Scope: many remedy types)
• Vitamin C - Solubilizes
• Almonds, Brazil nuts, Broccoli, Cauliflower, Collard greens, Dairy products, Hard water, Kale, Molasses, Salmon, Sardines, Seaweed / kelp, Soybeans, Tofu - Source Of
• Bone - Supplies (Condition: dietary deficiency; Purpose: cover requirements)
• Boron - Supports (Certainty: may; Condition: chronically low calcium)
• Vitamin K - Supports Utilization Of (Importance: important; Mechanism: osteocalcin)
• Copper, Potassium - Synergizes With
• Magnesium - Synergizes With (Condition: normal levels; Dependency: dose)
• People - Takes (Amount: as much as wanted; Outcome: get away with it; Claimant: quoted view)
• Bone metabolism - Uses (Efficiency: efficient)

Vitamin K2 - connections

Vitamin K2 ->

• Acts Through: Gamma-carboxyglutamic acid
• Acts Through: Osteocalcin (Emphasis: particular)
• Carboxylates: Osteocalcin (Necessity: dependent)
• Enables: Osteocalcin (Necessity: required; Aspect: proper_function)
• Maintains: Bone density (Comparison: better than vitamin D and synthetic estrogen)
• Maintains: Bone density (Comparison: more_than_vitamin_d_and_synthetic_estrogen)
• Prevents: Osteoporosis (Comparison: better than vitamin D and synthetic estrogen)
• Prevents: Bone loss (Comparison: more_than_vitamin_d_and_synthetic_estrogen)
• Prevents Calcification Of: Soft tissue (Intake: adequate; Mechanism: osteocalcin)
• Reduces: Arterial calcification (Evidence: research)
• Regulates: Calcium (Mechanism: gamma_carboxyglutamic_acid_and_osteocalcin)
• Slows: Calcium loss (Population: tendency_to_lose_calcium)
• Slows: Calcium loss (Population: those with a tendency to lose calcium)

-> Vitamin K2

• MK-7 - Is A (Preference: alternate)
• MK-4 - Is A (Preference: ideal)