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Dr. Ronald Roth Acu-Cell AI

Selenium Toxicity and Peripheral Neuropathy

Overview

Yes, excessive selenium intake can lead to toxicity, medically known as selenosis, which frequently affects the nervous system.
While selenium is an essential trace mineral required for antioxidant defense, thyroid function, and immune support, high doses over time become neurotoxic.

Neurological Symptoms of High Selenium

Peripheral neuropathy is a recognized manifestation of chronic selenium toxicity.
Affected individuals commonly report:
Numbness and a tingling sensation, typically starting in the extremities (hands and feet).
Burning sensations or abnormal skin sensitivity (paresthesia).
Muscle weakness, fatigue, and occasional motor function impairment.

Other Indicators of Excess Selenium

To properly assess toxicity, practitioners look for concurrent clinical signs of selenosis, which include:
Garlic-like odor on the breath and a metallic taste in the mouth.
Brittle hair, hair loss (alopecia), and changes in nail structure (whitening, fragility, or sloughing).
Gastrointestinal disturbances such as nausea and diarrhea.
Skin rashes or lesions.

Causation and Assessment

Toxicity almost exclusively occurs due to inappropriate supplementation rather than dietary sources alone (unless consuming excessive amounts of Brazil nuts over a long period).
Laboratory assessment typically involves evaluating whole blood, serum, or urine selenium levels to confirm overload and guide the removal of the offending supplement source.

AI-generated in the approach of Dr. Ronald Roth. Not his own words.

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Connections

Selenium - connections

Selenium ->

Affects: Central nervous system
Affects: ALS symptoms (Condition: lowered level; Outcome: improvement; Degree: pronounced; Duration: short-term; Basis: trial)
Affects: Muscle coordination, Speech (Condition: lowered level; Outcome: improvement; Degree: pronounced; Duration: short-term; Population: ALS patients; Basis: trial)
Affects Conversion: T4 (Product: triiodothyronine)
Antagonizes: Chromium
Antagonizes: Zinc (Frequency: common)
Associated With: Amyotrophic lateral sclerosis (Level: above normal; Location: intracellular)
Associated With: Alzheimer's disease (Level: below normal; Location: intracellular)
Associated With: Arthritis, Immune system dysfunctions, Type II diabetes (Level: high)
Associated With: Garlic breath odor (Level: high; Condition: without_eating_garlic)
Associated With: Cataracts, Immune system dysfunctions, Joint / bone pain (Level: low)
Associated With: Cancers (Level: low; Cancers: lung, skin, prostate, liver, colorectal, breast)
Associated With: Alzheimer's disease (Level: very low; Location: intracellular)
Associates With: Sulfur
Binds: Heavy metals (Quantity: multiple; Toxicity: toxic)
Causes: Bone loss (Condition: needless supplementation or prolonged high level; Mechanism: chromium antagonism)
Causes: Weight loss (Level: low)
Cautioned For: Compromised immune system
Contributes To: Bone loss (Condition: needless_supplementation_or_high_level; Modality: can)
Inhibits: Chromium
Opposes: Chromium
Pairs With: Sulfur
Protects Against: Arsenic, Cadmium, Lead, Mercury
Provokes: Inflammatory response (Condition: excessive uptake or retention; Example: ALS)
Provokes: Degenerative response (Condition: insufficient uptake or retention; Example: Alzheimer's disease)
Provokes: Inflammatory response (Uptake: excessive; Retention: excessive; Example: ALS; Location: central nervous system)
Provokes: Degenerative response (Uptake: insufficient; Retention: insufficient; Example: Alzheimer's disease; Location: central nervous system)
Supports: Rutin uptake
Supports: Human health (Necessity: essential)
Supports: Thyroid functions (Recommendation: check and correct status; Alternative to: vitamin B6 injections)
Supports: Thyroid functions (Recommendation: check_and_correct; Instead of: vitamin_b6_injections)
Treats: Acetaminophen overdose, Acetaminophen overdose / liver damage, Liver damage

-> Selenium

Alzheimer's disease - Affects (Aspect: intake)
Magnesium - Antagonizes
Amyotrophic lateral sclerosis - Associates With (Level: above_normal; Location: cellular)
Crohn's disease - Associates With (Level: above_normal; Location: cellular; Frequency: sometimes)
Excessive zinc intake - Disrupts Balance Of (Timing: eventually)
ALS patients - Has Level (Level: above-normal; Domain: intracellular chemistry)
Alzheimer's disease - Has Level (Level: low; Degree: very; Frequency: not always)
Amyotrophic lateral sclerosis - Involves Storage Of (Amount: excessive; Location: cellular)
Selenium antagonists - Lowers (Basis: trial)
Selenium levels - Measures
Crohn's disease - Requires Reduction Of (Amount: minimum; Frequency: sometimes)
Cellular storage - Stores
Electro-acupuncture therapy - Suppresses (Aspect: activity; Basis: trial; Location: strategic acupuncture points)
Vanadium - Synergizes With
Vitamin D - Synergizes With (Condition: normal levels; Dependency: dose)

Peripheral neuropathy - connections

-> Peripheral neuropathy

Folate, Pyridoxal-5-phosphate, Vitamin B12, Vitamin B15, Vitamin B6 - Associated With (Level: high)
Essential fatty acids, Folate, Inositol, Pyridoxal-5-phosphate, Vitamin B12, Vitamin B15, Vitamin B6, Vitamin E - Associated With (Level: low)

Nerve conduction - connections

-> Nerve conduction

Magnesium - Regulates (Together with: calcium)
Calcium - Regulates (Together with: magnesium)
Phosphorus - Supports (Quality: proper)

Can high vitamin B6 intake cause peripheral neuropathy? Can high dose vitamin B6 pyridoxine cause peripheral neuropathy? Can high selenium intake cause peripheral nerve neuropathy? Which nutrient deficiency contributes to peripheral neuropathy? Can high dose B vitamins cause nerve toxicity over time? Can high sodium intake increase peripheral resistance? Can high dose vitamin B6 cause sensory peripheral neuropathy? Can high cobalt intake cause nerve deafness toxicity? What heavy metal aluminum toxicity alters motor nerve conduction? Can cobalt toxicity cause nerve deafness sensorineural loss? Can low vitamin B12 cause optic neuropathy vision loss? Can prednisone cause peripheral edema and swelling in the feet and ankles? Can low cobalt intake cause fatigue and peripheral neuropathy? Does ginkgo biloba extract improve peripheral blood circulation? Can high selenium intake cause selenosis, resulting in hair loss and nail changes? Which high element causes garlic breath odor without garlic? Does high selenium intake elevate risk of Type II diabetes in trials? What mineral status is elevated in selenosis toxicity? Can high vitamin A intake cause liver toxicity symptoms? What skin symptom is associated with high vitamin A intake?

Overview

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