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Dr. Ronald Roth Acu-Cell AI

Selenium Status and Autoimmune Thyroiditis

Role of Selenium in Thyroid Health

The highest concentration of selenium per gram of tissue in the human body is found in the thyroid gland.
Selenium is an essential component of selenoproteins, particularly glutathione peroxidases and iodothyronine deiodinases, which protect the thyroid from oxidative damage during hormone synthesis.

Connection to Autoimmune Thyroiditis

A low selenium status significantly increases the risk and progression of autoimmune thyroiditis (such as Hashimoto's thyroiditis).
Selenium deficiency impairs antioxidant defense mechanisms within the thyroid, leading to cellular damage and the release of antigens that trigger an autoimmune response.
Clinical observations indicate that suboptimal selenium levels exacerbate inflammation and correlate with higher titers of thyroid peroxidase antibodies (TPOAb).

Nutritional and Clinical Implications

Maintaining adequate selenium levels helps modulate the immune system and reduces thyroid inflammation.
Supplementation with appropriate forms of selenium has been shown in various studies to successfully lower anti-thyroid antibody levels in patients with autoimmune thyroiditis.
Assessment of mineral status, including selenium, iodine, zinc, and iron, is crucial, as imbalances often coexist and impact overall endocrine and immune function.

AI-generated in the approach of Dr. Ronald Roth. Not his own words.

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Connections

Selenium - connections

Selenium ->

Affects: Central nervous system
Affects: ALS symptoms (Condition: lowered level; Outcome: improvement; Degree: pronounced; Duration: short-term; Basis: trial)
Affects: Muscle coordination, Speech (Condition: lowered level; Outcome: improvement; Degree: pronounced; Duration: short-term; Population: ALS patients; Basis: trial)
Affects Conversion: T4 (Product: triiodothyronine)
Antagonizes: Chromium
Antagonizes: Zinc (Frequency: common)
Associated With: Amyotrophic lateral sclerosis (Level: above normal; Location: intracellular)
Associated With: Alzheimer's disease (Level: below normal; Location: intracellular)
Associated With: Arthritis, Immune system dysfunctions, Type II diabetes (Level: high)
Associated With: Garlic breath odor (Level: high; Condition: without_eating_garlic)
Associated With: Cataracts, Immune system dysfunctions, Joint / bone pain (Level: low)
Associated With: Cancers (Level: low; Cancers: lung, skin, prostate, liver, colorectal, breast)
Associated With: Alzheimer's disease (Level: very low; Location: intracellular)
Associates With: Sulfur
Binds: Heavy metals (Quantity: multiple; Toxicity: toxic)
Causes: Bone loss (Condition: needless supplementation or prolonged high level; Mechanism: chromium antagonism)
Causes: Weight loss (Level: low)
Cautioned For: Compromised immune system
Contributes To: Bone loss (Condition: needless_supplementation_or_high_level; Modality: can)
Inhibits: Chromium
Opposes: Chromium
Pairs With: Sulfur
Protects Against: Arsenic, Cadmium, Lead, Mercury
Provokes: Inflammatory response (Condition: excessive uptake or retention; Example: ALS)
Provokes: Degenerative response (Condition: insufficient uptake or retention; Example: Alzheimer's disease)
Provokes: Inflammatory response (Uptake: excessive; Retention: excessive; Example: ALS; Location: central nervous system)
Provokes: Degenerative response (Uptake: insufficient; Retention: insufficient; Example: Alzheimer's disease; Location: central nervous system)
Supports: Rutin uptake
Supports: Human health (Necessity: essential)
Supports: Thyroid functions (Recommendation: check and correct status; Alternative to: vitamin B6 injections)
Supports: Thyroid functions (Recommendation: check_and_correct; Instead of: vitamin_b6_injections)
Treats: Acetaminophen overdose, Acetaminophen overdose / liver damage, Liver damage

-> Selenium

Alzheimer's disease - Affects (Aspect: intake)
Magnesium - Antagonizes
Amyotrophic lateral sclerosis - Associates With (Level: above_normal; Location: cellular)
Crohn's disease - Associates With (Level: above_normal; Location: cellular; Frequency: sometimes)
Excessive zinc intake - Disrupts Balance Of (Timing: eventually)
ALS patients - Has Level (Level: above-normal; Domain: intracellular chemistry)
Alzheimer's disease - Has Level (Level: low; Degree: very; Frequency: not always)
Amyotrophic lateral sclerosis - Involves Storage Of (Amount: excessive; Location: cellular)
Selenium antagonists - Lowers (Basis: trial)
Selenium levels - Measures
Crohn's disease - Requires Reduction Of (Amount: minimum; Frequency: sometimes)
Cellular storage - Stores
Electro-acupuncture therapy - Suppresses (Aspect: activity; Basis: trial; Location: strategic acupuncture points)
Vanadium - Synergizes With
Vitamin D - Synergizes With (Condition: normal levels; Dependency: dose)

Autoimmune diseases - connections

Autoimmune diseases ->

Associated With: Arrhythmia

-> Autoimmune diseases

Vitamin D - Worsens (Level: high; Modal: may; Aspect: symptoms)

Hashimoto's thyroiditis - connections

-> Hashimoto's thyroiditis

Adult iodine dose - Treats (Amount: 12.5 mg; Frequency: daily; Recommender: some practitioners)

Can low selenium status raise risk of autoimmune thyroiditis? Can excess iodine cause Hashimoto autoimmune thyroiditis flare? Does selenium supplementation lower thyroid peroxidase antibodies TPOAb? Can low stomach acid promote chronic autoimmune responses? Does Keshan disease cardiomyopathy result from low selenium? Can low selenium status lower thyroid peroxidase activity? Can low selenium status impair thyroid hormone conversion? Does selenium deficiency cause White Muscle disease in livestock? What selenium deficiency disease causes Keshan cardiomyopathy? Is selenium deficient in mid-stage Alzheimer's patients? How is Kashin-Beck disease linked to low selenium status? What selenium status is common in lung cancer risk? What selenium status is common in colorectal cancer risk? Can low selenium status raise prostate cancer risk? Does selenium status modulate viral mutation rates in RNA viruses? Does selenium status influence macrophage M1 M2 polarization? Does selenium status modulate prostate tissue cell growth? Does selenium status govern glutathione peroxidase 1 GPX1? Can AIP autoimmune protocol diet exclude nightshade plants? Can non secretors have higher autoimmune disease risks?

Overview

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