HealthMap

Nickel toxicity - connections

-> Nickel toxicity

• Nickel retention tendency - Causes (Amount: excessive; Origin: natural)
• Nickel - Causes (Amount: several grams; Route: ingested; Source: non-dietary; Frequency: usually not otherwise)
• Nickel carbonyl - Causes (Degree: quite)

Nickel - connections

Nickel ->

• Activates: Glucose-utilization enzymes (Certainty: may)
• Affects: Left coronary artery
• Affects: Adrenals, Thyroid gland (Pathway: direct or indirect)
• Affects: Cardiac function (Sequence: subsequently; Pathway: direct or indirect)
• Associated With: Chronic sinus headache (Level: considerably below normal; Scope: majority of patients)
• Associated With: Angina, Anxiety, Asthma, Diarrhea, Headaches, Hypoglycemia, Nausea, Shortness of breath, Skin rash, Stomach irritation, Vomiting (Level: high)
• Associated With: Acne (Level: high; Frequency: frequent)
• Associated With: Angina (Level: high; Side: left)
• Associated With: Anemia, Asthma, Depression, Fatigue, Hyperglycemia, Liver diseases, Sinus congestion, Type II diabetes (Level: low)
• Associates With: Cobalt
• Associates With: Vitamin C (Documentation: less)
• Benefits: Cirrhosis, Hypoadrenalism (Modality: can)
• Causes: Vasoconstriction
• Causes: Nickel toxicity (Amount: several grams; Route: ingested; Source: non-dietary; Frequency: usually not otherwise)
• Causes: Heart failure (Level: high; Intake multiple: 50000–100000; Reference: daily intake)
• Causes: Vasoconstriction (Level: high; Location: left coronary artery)
• Causes: Vasodilation (Level: low; Location: left coronary artery)
• Constitutes: Albumin, Nickeloplasmin (Location: plasma; Amount: most)
• Contributes To: Cell membrane metabolism, Hormone metabolism, Lipid metabolism (Certainty: thought)
• Controls: Arterial muscular walls (Documentation: less)
• Eliminated Via: Feces (Amount: most)
• Eliminated Via: Sweat (Amount: small)
• Eliminated Via: Urine (Amount: some)
• Increases: Red blood cells, Urinary protein (Level: high)
• Increases: Intracellular calcium ratio (Level: low; Timing: eventually)
• Increases: Copper bioavailability (Modal: may; Condition: low relative to copper)
• Increases: Insulin production (Modality: can)
• Increases: Insulin response (Timing: after ingestion)
• Inhibits: Calcium, Copper, Manganese, Phytic acid, Sodium, Vitamin E, Zinc
• Inhibits: Vitamin E (Condition: excess retention)
• Inhibits: Cobalt (Level: higher; Dependency: dose)
• Interacts With: DNA, RNA
• Links To: Dermatitis, Skin allergies (Context: eyeglass frames, dental materials, and costume jewelry)
• Modifies: Coronary arteries (Certainty: can; Properties: vasodilating or vasoconstrictive; Condition: Vitamin C/Vitamin E ratio conflict)
• Occurs In: DNA, RNA (Amount: significant)
• Pairs With: Cobalt
• Reduces: Vitamin C requirements (Amount: small; Degree: considerably; Evidence: some patients)
• Reduces: Vitamin C megadoses (Amount: small; Regimen: daily dietary or nutritional; Degree: considerably; Benefit: same)
• Reduces: Estrogen, Pulse (Level: high)
• Reduces: Adrenal function, Blood pressure, Stomach acid (Level: low)
• Reduces: Side effects (Mechanism: reduced Vitamin C requirements; Scope: rest of system)
• Resolves: Psychiatric misdiagnosis (Condition: abnormal status corrected; Modality: could)
• Synergizes With: Bismuth, Germanium, Iron, Phosphorus, Tin, Vitamin C
• Synergizes With: Cobalt (Level: normal; Dependency: dose)

-> Nickel

• Dr. Ronald Roth - Assesses (Frequency: every patient consultation)
• Cluster headache - Associated With (Level: very high; Pattern: one side-dependent chemistry; Frequency: generally)
• Iron-deficiency anemia - Co Occurs With (Frequency: often; Level: low)
• Excessive zinc intake - Disrupts Balance Of (Timing: eventually)
• Vitamin C, Vitamin E - Imbalances (Condition: unmatched increased intake; Certainty: can)
• Vitamin E - Inhibits
• Cobalt - Inhibits (Level: higher; Dependency: dose)
• Copper - Inhibits (Level: overload)
• Copper - Opposes (State: elevated)
• Kidneys - Regulates (Process: retention; Process scope: elimination)
• Beans, Buckwheat seed, Herring, Lentils, Nuts, Oats, Oysters, Peas, Soybeans, Tea, Unrefined whole grains - Source Of
• Cobalt - Synergizes With (Level: normal; Dependency: dose)

DNA damage - connections

DNA damage ->

• Increases Production Of: WNT16B protein

-> DNA damage

• Quercetin - Causes (Amount: 50-250 micromol/L; Evidence: rat studies; Study count: a number)
• Bioflavonoids - Causes (Concentration: high; Certainty: apparently; Location: rat H4IIE cells)
• Chemotherapy - Causes (Target: noncancerous cells; Location: surrounding solid tumors)