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Dr. Ronald Roth Acu-Cell AI

Fluoride and the Enzyme Enolase

Yes, fluoride acts as a potent metabolic inhibitor of the glycolytic enzyme enolase.
This inhibition occurs because fluoride ions, in the presence of magnesium and phosphate, form a complex that strongly binds to the active site of the enolase enzyme.
By blocking enolase, fluoride effectively disrupts the normal pathway of glycolysis, preventing the conversion of 2-phosphoglycerate to phosphoenolpyruvate.
Consequently, this enzymatic blockage leads to a significant reduction in cellular energy (ATP) production and decreases lactic acid formation within affected cells.

AI-generated in the approach of Dr. Ronald Roth. Not his own words.

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Connections

Fluoride - connections

Fluoride ->

Affects: Intellectual development (Polarity: no credible evidence; Source: industrial pollution; Population: children)
Affects: Intellectual development (Polarity: no credible evidence; Source: water; Population: children)
Associated With: Dizziness, Goiter, Mottled teeth (Level: high)
Associated With: Tinnitus (Level: high; Side: left)
Causes: Osteoporosis (Certainty: can; Level: high)
Causes: Osteoporosis (Certainty: can; Level: low)
Causes: Tooth mottling (Level: excess; Location: certain regions; Population: children; Certainty: argued)
Causes: Bone brittleness (Level: high)
Causes: Hearing loss (Level: high; Modality: may; Timing: eventually; Progression: progressive)
Causes: Cancers (Polarity: no evidence; Population: humans; Source: 1991 Public Health Service review)
Decreases In: Bone (Intake: reduced; Duration: long; Timing: subsequently; Measure: concentration)
Has Value In: Human nutrition (Controversy: present; Certainty: disputed)
Impairs: Bowel functions, Sinuses (Level: low; Direction: adverse; Tendency: tend)
Increases: Bone mass
Increases: Bone brittleness (Level: excessive)
Increases: Congested sinuses, Inflammation (Level: low; Measure: incidence; Degree: greater)
Increases: Birth defects, Intestinal problems, Kidney diseases (Polarity: does not; Level: current; Medium: drinking water; Measure: risk)
Interacts With: Carotenoids (Quantity: some)
Is Essential To: Human health (Certainty: considered; Controversy: present)
Lowers: IQ (Exposure: high; Comparison: low exposure; Population: children; Certainty: claimed; Study count: two)
Lowers: IQ, Learning ability (Intake: high; Certainty: implicated; Evidence: numerous studies)
Mobilizes: Bound fluoride (Intake: reduced; Duration: long)
Pairs With: Chloride
Pairs With: Chloride (Association: associated)
Relates To: Fractures (Certainty: undetermined; Measure: intake; Scope: bone)
Triggers: Tinnitus (Level: high; Modality: can)

-> Fluoride

Gastrointestinal tract - Absorbs
Inhalation - Absorbs (Modality: may)
Municipalities - Adds (Destination: drinking water)
Water hardness - Affects (Process: uptake; Degree: some)
Dr. Ronald Roth - Assesses (Frequency: every patient consultation)
Strontium - Lowers (Modal: potential)
1991 Public Health Service review - Recommends Studying (Topic: bone fractures; Focus: intake relationship; Extent: further)
Soluble fluoride compounds - Supplies (Extent: nearly all; Condition: ingested with water; Modality: may)

Digestive enzyme complex - connections

Digestive enzyme complex ->

Is A: Pancreatic enzymes
Treats: Bloating (Location: below_navel; Targets: lactose_fiber_other_gas_causing_agents)

Cells - connections

-> Cells

Osmotic pressure - Develops Between
Magnesium - Is Found In (Proportion: most)
Calcium - Is Found In (Proportion: part of remainder)
Superoxide dismutase - Protects
Uric acid - Protects (Level: normal; Threat: free radicals)

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