HealthMap

Folate - connections

Folate ->

• Affects: Insulin/glucose metabolism
• Associated With: Anorexia, Apathy, Constipation, Hypotension, Leukopenia, Miscarriages, Peripheral neuropathy (Level: high)
• Associated With: Cancers (Level: high; Cancers: breast, prostate, lung, colon; Condition: high vitamin B12 for lung and colon; Evidence: breast preliminary or animal data)
• Associated With: Stomach acid (Level: high; Target level: high)
• Associated With: Anemia, Anorexia, Apathy, Arrhythmia, Asthma, Burning feet, Diarrhea, Digestive problems, Fatigue, Glaucoma, Glossitis, High blood pressure, Low sperm count, Miscarriages, Ménière's disease, Peripheral neuropathy, Slow or impaired growth, Sodium retention (Level: low)
• Associated With: Cancers (Level: low; Cancers: colon, breast, lung, pancreatic)
• Associated With: Stomach acid (Level: low; Target level: low)
• Associated With: Eclampsia or pre-eclampsia, Preeclampsia / Eclampsia (Level: low; Timing: pregnancy)
• Causes: Restless Leg Syndrome (State: deficient; Frequency: some cases)
• Inhibits: Iron (Condition: kidney disease and imbalance)
• Lowers: Dopamine production (State: deficient)
• Reduces: Sodium (State: elevated)

-> Folate

• Magnesium - Antagonizes
• Iron - Inhibits (Condition: kidney disease and imbalance)
• UV exposure - Lowers (Certainty: associated; Level: decreased)
• Folic acid - More Potent Than (Degree: about_twice)
• Kidney diseases - Requires Balance With (Counterpart: iron; Degree: fine)

Homocysteine - connections

Homocysteine ->

• Associated With: Cardiovascular disease with artery-wall damage (Level: high)
• Contributes To: Cardiovascular disease (Certainty: believed)
• Damages: Endothelium (Certainty: believed)
• Is A: Sulfur-containing compounds (Importance: primary; Context: nutrition)

-> Homocysteine

• Folic acid - Associated With (Level: low; Target level: higher)
• Vegetarians - Has (Frequency: many; Tendency: high side)
• Folic acid, Vitamin B12, Vitamin B6 - Lowers (Ability: able)
• Choline, PABA, Vitamin B12, Vitamin B6 - Lowers (Location: blood)
• Folic acid - Lowers (Location: blood; Dose: less_than_1_mg_per_day_sufficient)

Folic acid - connections

Folic acid ->

• Antagonizes: Zinc (Frequency: common)
• Associated With: Cardiovascular disease with coronary artery blockage (Intake: high; Duration: long_term)
• Associated With: Asthma, Kidney damage, Nausea, Pernicious anemia, Respiratory tract infections (Level: high)
• Associated With: Abdominal bloating (Level: high; Alternative: distention)
• Associated With: Appetite (Level: high; Target level: lost)
• Associated With: Cardiovascular disease with artery-wall damage, Cervical dysplasia, Confusion, Depression, Forgetfulness, Hemolytic anemia, Insomnia, Irritability, Leukemia, Megaloblastic anemia, Mental disorders, Pernicious anemia, Vascular degeneration (Level: low)
• Associated With: Fetal development (Level: low; State: abnormal)
• Associated With: Blood pressure (Level: low; Target level: high)
• Associated With: Homocysteine (Level: low; Target level: higher)
• Associated With: Energy (Level: low; Target level: low)
• Benefits: Sodium sensitivity (Certainty: might; Amount: extra)
• Benefits: Hyperadrenalism (Certainty: might; Amount: extra; Predisposition: tendency)
• Causes: Nerve damage (Condition: regular supplementation causing Vitamin B12 deficiency; Modality: potential; Permanence: permanent)
• Causes: Vitamin B12 deficiency (Frequency: regularly; Modality: can)
• Improves: Coronary heart disease (Certainty: conflicting_evidence; Mechanism: homocysteine_reduction)
• Increases: Cholesterol LDL/HDL ratio, Potassium requirements, Zinc requirements (Level: high)
• Increases Risk Of: Cancers (Amount: high; Condition: not_indicated; Scope: some; Combination: vitamin_b12)
• Increases Risk Of: Oral cleft malformations (Level: high)
• Increases Risk Of: Cancers (Level: high; Scope: some; Condition: vitamin_b12_supplementation)
• Increases Risk Of: Cancers (Level: low; Scope: some)
• Interacts With: Vitamin B12
• Interacts With: Headaches (Level: too low)
• Lowers: Sodium
• Lowers: Homocysteine (Ability: able)
• Lowers: Sodium (Amount: higher; Recommendation: should have been supplemented; Condition: toxemia context)
• Lowers: Homocysteine (Location: blood; Dose: less_than_1_mg_per_day_sufficient)
• Masks: Pernicious anemia (Level: high; Modal: may; Cause: vitamin_b12_deficiency)
• More Potent Than: Folate (Degree: about_twice)
• Prevents: Folate deficiency (Certainty: may; Context: vitamin_b12_supplementation)
• Prevents: Red blood cells (Intake: high; Object: Vitamin B12-deficiency changes)
• Prevents: Nerve damage (Polarity: negative; Cause: Vitamin B12 deficiency)
• Protects Against: Birth defects (Certainty: possibly; Population: newborns; Scope: other; Dose: up_to_5_mg_per_day; Risk: high; Timing: start_2_to_3_months_before_conception)
• Protects Against: Neural tube defects (Population: newborns; Dose: up_to_5_mg_per_day; Risk: high; Timing: start_2_to_3_months_before_conception)
• Taken With: Eggs (Timing: morning-afternoon)
• Worsens: Childhood leukemia (Level: high; Scope: some_types)

-> Folic acid

• Vitamin C - Metabolizes
• Intestinal bacteria - Produces
• Vitamin B12 - Requires Supplementation With (Level: high; Duration: long-term; Purpose: prevent listed anemia and sensory symptoms)