HealthMap

Copper - connections

Copper ->

• Antagonizes: Chromium, Sulfur, Zinc
• Antagonizes: Sulfur (Degree: potent; Domain: dietary)
• Associated With: Nausea (Intake: high)
• Associated With: Aneurysms, Apathy, Arthritis, Bleeding gums, Bruising, Cardiovascular disease with artery-wall damage, Cardiovascular disease with coronary artery blockage, Depression, Fatigue, Fibroid tumors, Hyperactivity, Immune system dysfunctions, Insomnia, Joint / bone pain, Learning disability, Memory impairment, Moodiness, Nose bleeds, Periodontal disease, Poor wound healing, Soft-tissue calcification, Yeast infection / Candida vulvovaginitis (Level: high)
• Associated With: Hemangiomas (Level: high; Location: liver)
• Associated With: Cancers (Level: high; Scope: most cancers)
• Associated With: Aneurysms, Arrhythmia, Arthritis, Bruising, Cardiovascular disease with artery-wall damage, Graying hair, Immune system dysfunctions, Insomnia, Joint / bone pain, Menopausal flushing, Nose bleeds, Periodontal disease, Poor wound healing, Yeast infection / Candida vulvovaginitis (Level: low)
• Associated With: Bleeding gums (Level: low; Degree: very)
• Associated With: Allergies (Level: low; Frequency: frequent)
• Associated With: Colon cancer (Level: low; Metastasis condition: must remain low with organ metastasis)
• Associated With: Blepharitis, Conjunctivitis (Level: low; Side: right; Frequency: usually; Severity: worse)
• Associates With: Joint degenerative condition (Level: excessive; Frequency: generally; Scope: many)
• Associates With: Calcium, Potassium (Source level: low; Target level: low; Frequency: frequently)
• Catalyzes: Hemoglobin (Importance: important)
• Causes: Osteoporosis (Certainty: can; Level: high)
• Causes: Osteoporosis (Certainty: can; Level: low)
• Causes: Bone loss (Condition: needless supplementation or prolonged high level; Mechanism: chromium antagonism)
• Causes: Weight gain (Frequency: frequent; Context: supplementation_or_chocolate_content)
• Causes: Excessive blood-thinning (Intake: low)
• Causes: Vascular degeneration (Level: excess; Laterality: right; Certainty: invariably)
• Causes: Joint degeneration (Level: high)
• Causes: Medical symptoms (Level: high; Condition: Vitamin C dose reduced below 5,000–10,000 mg range; Timing: as soon as reduced)
• Causes: Vitamin C deficiency (Level: high; Form: pseudo)
• Causes: Osteoarthritis (Level: high; Frequency: common; Alternative: aggravates; Mechanism: lowered_sulfur)
• Causes: Arteriosclerosis (Level: high; Modal: can)
• Causes: Arteriosclerosis (Level: high; Modality: can)
• Causes: Weight loss (Level: low)
• Causes: Leg bone malformation (State: deficient; Severity: severe; Duration: long-term; Progression: increasing)
• Cautioned For: Compromised immune system
• Component Of: Cytochrome oxidase, Dopamine-beta-hydroxylase, Histaminase, Lysil oxidase, Physiologically important enzymes, Superoxide dismutase, Tyrosinase (Necessity: essential)
• Contributes To: Healthy bones
• Contributes To: Bone loss (Condition: needless_supplementation_or_high_level; Modality: can)
• Contributes To: Spinal degeneration (Level: very high; Certainty: very likely)
• Decreases: Copper bioavailability (Level: high; Modal: can)
• Enables: Angiogenesis (Importance: important)
• Enables: Angiogenesis (Role: important cofactor; Location: tumors)
• Enables Synthesis Of: Norepinephrine (Role: cofactor; Partner: dopamine-beta-hydroxylase)
• Exceeds: Chromium (Frequency: invariably; Degree: much_higher)
• Exceeds: Chromium (Frequency: virtually always; Measure: level)
• Exhibits: Anti-inflammatory properties, Degenerative properties (Level: higher)
• Formed Into: Ceruloplasmin (Location: liver)
• Forms: Copper salts (Condition: reaction with skin fatty acids)
• Harms: Concentration, Memory (Level: elevated; Modal: can; Mechanism: sulfur_inhibition)
• Has: Right-sided cell receptor
• Helps: Iron (Process: hemoglobin formation; Location: bone marrow)
• Improves: Stress-coping ability (Certainty: even; Dosage effect: calming)
• Increases: Vascular degeneration (Level: high; Aspect: risk; Degree: greater)
• Increases: Intracellular calcium (Level: higher; Manner: synergistically)
• Increases: Medical problems (Level: steadily_increasing; Timing: over_time)
• Increases Risk Of: Cancers, Cardiovascular disease, Joint degeneration, Mental health issues
• Increases Risk Of: Tumors (Extent: some; Types: benign and malignant)
• Increases Risk Of: Vascular degeneration (Level: high)
• Increases Risk Of: Colorectal cancer (Level: insufficient; Location: cellular; Modality: more likely)
• Inhibits: Hesperidin (Aspect: action)
• Inhibits: Hesperidin, Vitamin C (Frequency: most common; Potency: potent)
• Inhibits: Chromium, Hesperidin, Molybdenum, Nickel, Sulfur, Vitamin C (Level: overload)
• Inhibits: Flavonoid activity (Level: steadily_increasing)
• Interacts With: Headaches (Level: too high)
• Interferes With: Nickel metabolism, Vitamin C metabolism (Level: very high)
• Is A: Trace elements
• Is A: Sulfur antagonists (Degree: potent; Domain: dietary)
• Is Associated With: Depression (Source state: high)
• Is Associated With: Depression (Source state: low)
• Lowers: Sulfur (Level: high)
• Opposes: Chromium, Sulfur
• Opposes: Vitamin C (Rank: top)
• Opposes: Chromium, Hesperidin, Molybdenum, Nickel, Sulfur, Vitamin C (State: elevated)
• Present In: Tissues (Scope: all)
• Promotes: Alzheimer's disease (Exposure: above normal)
• Promotes: Joint degeneration (Level: elevated; Location: right_body_side; Degree: greater)
• Promotes: Osteoporosis (Level: high; Condition: low_chromium)
• Promotes: Arthritis, Inflammatory diseases (Level: high; Condition: low_chromium; Frequency: frequently)
• Provokes: Inflammatory response (State: deficient)
• Reacts With: Fatty acids in skin (Source: bracelets)
• Reduces: Inflammation, Inflammatory conditions
• Reduces: Osteoporosis (Aspect: risk)
• Reduces: Vitamin C (Level: very high; Outcome: below optimum; Exception: Vitamin C supplementation above 1,000 mg/day or prior copper reduction; Frequency: rarely reach optimum)
• Reduces: Copper bioavailability (Storage: excessive)
• Reduces Absorption Of: Zinc in food (Amount: high; Timing: concurrent)
• Stored In: Liver (Amount: most)
• Supports: Estrogen receptor-positive tumors (Level: higher; Mechanism: angiogenesis; Degree: particularly)
• Supports: Human health (Necessity: essential)
• Supports: Angiogenesis (Necessity: necessary)
• Synergizes With: Calcium, Potassium
• Triggers: Joint degeneration (Level: high; Modality: may)
• Triggers: Blepharitis, Conjunctivitis (State: deficient; Onset: acute; Condition: short course of very high Vitamin C intake)
• Weakens: Trabecular bone (Level: high; Condition: low_chromium)
• Weakens: Blood vessels (Level: low; Certainty: can_be_implicated; Effects: weak_fragile)
• Weakens: Blood vessels (Level: low; Effect: weak; Modality: may)
• Weakens: Blood vessels (Level: low; Modal: may; State: weak_or_fragile)

-> Copper

• Magnesium, Molybdenum, Sulfur, Zinc - Antagonizes
• Chromium - Associated With
• Fibroids, Hemangiomas - Associated With (Level: elevated)
• Benign tumors, Malignant tumors - Associated With (Scope: most_types; Level: elevated)
• Chromium - Associates With
• Chromium - Associates With (Degree: closest)
• Albumin - Carries (Destination: liver)
• Vitamin C - Causes (Dose: 2,000 mg/day; Timing: from an early age; Outcome: deficiency; Severity: severe; Duration: long-term)
• Vitamin C - Causes Deficiency Of (Amount: excessive_or_overdose; Certainty: potential; Timing: eventual; Susceptibility: prone)
• AAACa / AdvaCAL Calcium - Changes (Degree: notable; Timing: after a very short trial)
• Bronze - Contains
• Cocoa - Contains (Amount: considerable)
• Cocoa products, Coffee - Contains (Bioavailability: much_higher; Comparison: higher_level_sources)
• Cola drinks, Liver, Nuts, Processed cocoa products, Shellfish, Soy products, Wheat germ - Contains (Level: high)
• Nuts and seeds - Contains (Level: high; Scope: some)
• Bitter chocolate - Contains (Level: highest)
• Light chocolate, Milk chocolate - Contains (Level: lowest)
• Cocoa - Contains (Level: moderately high)
• Mineral formulations - Contains (Threshold: more than 0.5 mg)
• Glucosamine sulfate, MSM - Counteracts (Condition: successful; Degree: partly; Level: high)
• Vitamin C overdose - Deplete (Frequency: regularly; Progression: gradual; Initial state: higher stores)
• Excessive zinc intake - Disrupts Balance Of (Timing: eventually)
• Copper supplementation - Elevates (Modal: may; Condition: not discontinued or reduced)
• Copper-rich foods - Elevates (Modal: may; Duration: chronic)
• One-sided diets - Elevates (Modal: may; Duration: chronic; Condition: lacks cofactors or copper antagonists)
• Multivitamin/mineral supplement - Excludes (Recommendation: should; Condition: tendency to retain too much copper)
• High-copper, low-sulfur chemical pattern - Has Level (Level: high)
• Chocoholics - Has Level (Level: high_or_excessive; Frequency: most; Basis: highest_chocolate_intake)
• Chromium, Molybdenum, Sulfur, Vitamin C - Increases (Aspect: bioavailability; Intake: greater)
• Copper bracelets - Increases (Condition: copper low; Modal: can)
• Estrogen therapy - Increases (Frequency: sometimes; Condition: hemangioma)
• Nickel - Inhibits
• Molybdenum, Sulfur - Inhibits (Condition: supplementation; Location: humans)
• Sulfur - Inhibits (Process: storage; Generality: general; Effect: positive; Condition: high_copper_common)
• Tin - Is Less Toxic Than (Degree: far)
• Chromium, Glucosamine sulfate, Molybdenum - Lowers
• Copper antagonists, Copper co-factors - Lowers (Amount: excessive; Modal: may)
• Vitamin C - Lowers (Amount: larger; Condition: copper high)
• Vitamin C - Lowers (Dose: a few thousand mg; Condition: copper initially low; Outcome: deficient)
• Avoidance of copper-rich foods - Lowers (Importance: important)
• MSM - Lowers (Importance: main action)
• Vitamin C - Lowers (Initial level: excessively high; Evaluation: ideal remedy)
• Chromium supplementation - Lowers (Timing: initially; Frequency: generally)
• Chromium - Lower Than (Average: true; Frequency: always; Exceptions: virtually none)
• Chromium, Molybdenum, Sulfur, Vitamin C - Normalizes
• Chromium - Normalizes (Priority: first)
• Zinc - Opposes (Strength: weakest; Location: intestinal)
• Chromium - Pairs With
• Glucosamine sulfate, MSM - Reduces (Baseline: elevated; Importance: major)
• Chromium, Molybdenum, Sulfur, Vitamin C - Reduces (Intake: greater)
• Liver, Nuts, Shellfish, Soybeans, Wheat germ - Source Of
• Chocolate, Cocoa products, Coffee, Colas - Source Of (Consumption: common; Characterization: addictive)
• Liver, Nuts, Seafood, Seeds, Shellfish, Soy products - Supplies
• Copper containers - Supplies (Route: cooked or stored food and beverages)
• Copper IUDs - Supplies (Route: non-dietary)
• Beer - Supplies (Source: copper container)
• Tap water - Supplies (Source: copper plumbing)
• Aluminum, Calcium, Potassium - Synergizes With
• Zinc - Threatens (Condition: copper low or potassium and calcium below normal; Amount: high)
• Albumin - Transfers (Location: across gut wall)
• Ceruloplasmin - Transports

Nickel - connections

Nickel ->

• Activates: Glucose-utilization enzymes (Certainty: may)
• Affects: Left coronary artery
• Affects: Adrenals, Thyroid gland (Pathway: direct or indirect)
• Affects: Cardiac function (Sequence: subsequently; Pathway: direct or indirect)
• Associated With: Chronic sinus headache (Level: considerably below normal; Scope: majority of patients)
• Associated With: Angina, Anxiety, Asthma, Diarrhea, Headaches, Hypoglycemia, Nausea, Shortness of breath, Skin rash, Stomach irritation, Vomiting (Level: high)
• Associated With: Acne (Level: high; Frequency: frequent)
• Associated With: Angina (Level: high; Side: left)
• Associated With: Anemia, Asthma, Depression, Fatigue, Hyperglycemia, Liver diseases, Sinus congestion, Type II diabetes (Level: low)
• Associates With: Cobalt
• Associates With: Vitamin C (Documentation: less)
• Benefits: Cirrhosis, Hypoadrenalism (Modality: can)
• Causes: Vasoconstriction
• Causes: Nickel toxicity (Amount: several grams; Route: ingested; Source: non-dietary; Frequency: usually not otherwise)
• Causes: Heart failure (Level: high; Intake multiple: 50000–100000; Reference: daily intake)
• Causes: Vasoconstriction (Level: high; Location: left coronary artery)
• Causes: Vasodilation (Level: low; Location: left coronary artery)
• Constitutes: Albumin, Nickeloplasmin (Location: plasma; Amount: most)
• Contributes To: Cell membrane metabolism, Hormone metabolism, Lipid metabolism (Certainty: thought)
• Controls: Arterial muscular walls (Documentation: less)
• Eliminated Via: Feces (Amount: most)
• Eliminated Via: Sweat (Amount: small)
• Eliminated Via: Urine (Amount: some)
• Increases: Red blood cells, Urinary protein (Level: high)
• Increases: Intracellular calcium ratio (Level: low; Timing: eventually)
• Increases: Copper bioavailability (Modal: may; Condition: low relative to copper)
• Increases: Insulin production (Modality: can)
• Increases: Insulin response (Timing: after ingestion)
• Inhibits: Calcium, Copper, Manganese, Phytic acid, Sodium, Vitamin E, Zinc
• Inhibits: Vitamin E (Condition: excess retention)
• Inhibits: Cobalt (Level: higher; Dependency: dose)
• Interacts With: DNA, RNA
• Links To: Dermatitis, Skin allergies (Context: eyeglass frames, dental materials, and costume jewelry)
• Modifies: Coronary arteries (Certainty: can; Properties: vasodilating or vasoconstrictive; Condition: Vitamin C/Vitamin E ratio conflict)
• Occurs In: DNA, RNA (Amount: significant)
• Pairs With: Cobalt
• Reduces: Vitamin C requirements (Amount: small; Degree: considerably; Evidence: some patients)
• Reduces: Vitamin C megadoses (Amount: small; Regimen: daily dietary or nutritional; Degree: considerably; Benefit: same)
• Reduces: Estrogen, Pulse (Level: high)
• Reduces: Adrenal function, Blood pressure, Stomach acid (Level: low)
• Reduces: Side effects (Mechanism: reduced Vitamin C requirements; Scope: rest of system)
• Resolves: Psychiatric misdiagnosis (Condition: abnormal status corrected; Modality: could)
• Synergizes With: Bismuth, Germanium, Iron, Phosphorus, Tin, Vitamin C
• Synergizes With: Cobalt (Level: normal; Dependency: dose)

-> Nickel

• Dr. Ronald Roth - Assesses (Frequency: every patient consultation)
• Cluster headache - Associated With (Level: very high; Pattern: one side-dependent chemistry; Frequency: generally)
• Iron-deficiency anemia - Co Occurs With (Frequency: often; Level: low)
• Excessive zinc intake - Disrupts Balance Of (Timing: eventually)
• Vitamin C, Vitamin E - Imbalances (Condition: unmatched increased intake; Certainty: can)
• Vitamin E - Inhibits
• Cobalt - Inhibits (Level: higher; Dependency: dose)
• Copper - Inhibits (Level: overload)
• Copper - Opposes (State: elevated)
• Kidneys - Regulates (Process: retention; Process scope: elimination)
• Beans, Buckwheat seed, Herring, Lentils, Nuts, Oats, Oysters, Peas, Soybeans, Tea, Unrefined whole grains - Source Of
• Cobalt - Synergizes With (Level: normal; Dependency: dose)

Intestinal calcium absorption - connections

-> Intestinal calcium absorption

• Vitamin D - Assists
• Vitamin D - Increases
• Parathyroid hormones - Increases (Condition: as needed)