HealthMap

Open on a desktop browser to explore the interactive map. The knowledge graph needs a larger screen and a pointer. On this device you are limited to the text below.

Dr. Ronald Roth Acu-Cell AI

Selenium-Dependent Deiodinase and Thyroid Hormones

Yes, absolutely: Selenium-dependent enzymes known as iodothyronine deiodinases (specifically Type 1 and Type 2) are the primary catalysts responsible for converting the inactive storage thyroid hormone T4 (thyroxine) into the metabolically active hormone T3 (triiodothyronine).
The Role of Selenium: These deiodinase enzymes require the essential trace mineral selenium—specifically in the form of the amino acid selenocysteine—to function properly. Without adequate selenium levels, this crucial conversion process is impaired.
Clinical Implications: A deficiency in selenium can lead to a functional hypothyroid state where T4 levels may appear normal, but insufficient T3 is produced, negatively impacting cellular metabolism, energy production, and overall endocrine health.

AI-generated in the approach of Dr. Ronald Roth. Not his own words.

Traversing graph…

Connections

Selenium - connections

Selenium ->

Affects: Central nervous system
Affects: ALS symptoms (Condition: lowered level; Outcome: improvement; Degree: pronounced; Duration: short-term; Basis: trial)
Affects: Muscle coordination, Speech (Condition: lowered level; Outcome: improvement; Degree: pronounced; Duration: short-term; Population: ALS patients; Basis: trial)
Affects Conversion: T4 (Product: triiodothyronine)
Antagonizes: Chromium
Antagonizes: Zinc (Frequency: common)
Associated With: Amyotrophic lateral sclerosis (Level: above normal; Location: intracellular)
Associated With: Alzheimer's disease (Level: below normal; Location: intracellular)
Associated With: Arthritis, Immune system dysfunctions, Type II diabetes (Level: high)
Associated With: Garlic breath odor (Level: high; Condition: without_eating_garlic)
Associated With: Cataracts, Immune system dysfunctions, Joint / bone pain (Level: low)
Associated With: Cancers (Level: low; Cancers: lung, skin, prostate, liver, colorectal, breast)
Associated With: Alzheimer's disease (Level: very low; Location: intracellular)
Associates With: Sulfur
Binds: Heavy metals (Quantity: multiple; Toxicity: toxic)
Causes: Bone loss (Condition: needless supplementation or prolonged high level; Mechanism: chromium antagonism)
Causes: Weight loss (Level: low)
Cautioned For: Compromised immune system
Contributes To: Bone loss (Condition: needless_supplementation_or_high_level; Modality: can)
Inhibits: Chromium
Opposes: Chromium
Pairs With: Sulfur
Protects Against: Arsenic, Cadmium, Lead, Mercury
Provokes: Inflammatory response (Condition: excessive uptake or retention; Example: ALS)
Provokes: Degenerative response (Condition: insufficient uptake or retention; Example: Alzheimer's disease)
Provokes: Inflammatory response (Uptake: excessive; Retention: excessive; Example: ALS; Location: central nervous system)
Provokes: Degenerative response (Uptake: insufficient; Retention: insufficient; Example: Alzheimer's disease; Location: central nervous system)
Supports: Rutin uptake
Supports: Human health (Necessity: essential)
Supports: Thyroid functions (Recommendation: check and correct status; Alternative to: vitamin B6 injections)
Supports: Thyroid functions (Recommendation: check_and_correct; Instead of: vitamin_b6_injections)
Treats: Acetaminophen overdose, Acetaminophen overdose / liver damage, Liver damage

-> Selenium

Alzheimer's disease - Affects (Aspect: intake)
Magnesium - Antagonizes
Amyotrophic lateral sclerosis - Associates With (Level: above_normal; Location: cellular)
Crohn's disease - Associates With (Level: above_normal; Location: cellular; Frequency: sometimes)
Excessive zinc intake - Disrupts Balance Of (Timing: eventually)
ALS patients - Has Level (Level: above-normal; Domain: intracellular chemistry)
Alzheimer's disease - Has Level (Level: low; Degree: very; Frequency: not always)
Amyotrophic lateral sclerosis - Involves Storage Of (Amount: excessive; Location: cellular)
Selenium antagonists - Lowers (Basis: trial)
Selenium levels - Measures
Crohn's disease - Requires Reduction Of (Amount: minimum; Frequency: sometimes)
Cellular storage - Stores
Electro-acupuncture therapy - Suppresses (Aspect: activity; Basis: trial; Location: strategic acupuncture points)
Vanadium - Synergizes With
Vitamin D - Synergizes With (Condition: normal levels; Dependency: dose)

T4 - connections

T4 ->

Converts To: T3 (Affected by: selenium)
Is A: Thyroid hormones

-> T4

Vitamin B6 - Affects (Scope: only)
Selenium - Affects Conversion (Product: triiodothyronine)
Nickel and cobalt pair - Associated With
Tyrosine - Forms (Combination: iodine)
Iodine - Forms (Combination: tyrosine)
Bromine - Inhibits

T3 - connections

-> T3

T4 - Converts To (Affected by: selenium)
Vitamin B6 - Converts To (Polarity: negative)
Bromine - Inhibits

Does selenium dependent deiodinase convert T4 to active T3? Can low selenium status impair T4 to T3 thyroid conversion? Can low selenium status lower thyroid T4 to T3 conversion? Does vitamin B6 convert T4 to T3 thyroid hormone? What essential halogen iodine forms thyroid hormones T4 and T3? Does boron influence thyroid hormone T3 and T4 levels? Which mineral acts as a dose-dependent antagonist to calcium? Does selenium deficiency impair thyroid deiodinase enzymes? Does selenium support thyroid deiodinase during fever stress? Does selenium deficiency impair thyroid hormone T3 activation? What selenium status is common in colorectal cancer risk? What selenium status is common in rheumatoid arthritis? Which high element causes garlic breath odor without garlic? Does glutathione peroxidase enzyme use selenium cofactors? Can low selenium status lower thyroid peroxidase activity? Can low selenium status raise prostate cancer risk? What food source brazil nuts provides high dietary selenium? Can low selenium status impair thyroid hormone conversion? What selenium protein selenoprotein P transports selenium? Does low stomach acid lower intestinal selenium absorption?

Overview

Loading graph...

Display TOP 100%

Loading full knowledge graph…

Building graph…

Preparing…

Filter by Relationship

Filter by Type

Some information may be incomplete, disputed, or incorrect. Review the supporting sources.