HealthMap

Open on a desktop browser to explore the interactive map. The knowledge graph needs a larger screen and a pointer. On this device you are limited to the text below.

Dr. Ronald Roth Acu-Cell AI

Selenium and Thyroid Deiodinase During Fever Stress

Critical Role of Selenium: Selenium is an essential trace mineral required for the normal function of iodothyronine deiodinases, the enzymes responsible for converting the inactive thyroid hormone thyroxine ($T_4$) into the active form triiodothyronine ($T_3$).
Impact of Fever Stress: During periods of acute physiological stress, infection, or fever, the body's metabolic demands shift. Fever and inflammation can alter normal thyroid hormone metabolism, often leading to a temporary reduction in peripheral $T_3$ conversion as a protective mechanism to conserve energy.
Enzyme Protection and Function: Adequate selenium levels ensure that deiodinase enzymes remain structurally sound and functional during oxidative stress associated with fevers. A deficiency in selenium can impair this conversion pathway, potentially worsening fatigue and sluggish recovery during illness.
Nutritional Balance: While selenium supports deiodinase activity, supplementation should be balanced carefully. Excessive intake can lead to toxicity, so maintaining optimal nutritional status rather than high-dose megadosing is generally recommended to support the body's natural response to stress and infection.

AI-generated in the approach of Dr. Ronald Roth. Not his own words.

Traversing graph…

Connections

Selenium - connections

Selenium ->

Affects: Central nervous system
Affects: ALS symptoms (Condition: lowered level; Outcome: improvement; Degree: pronounced; Duration: short-term; Basis: trial)
Affects: Muscle coordination, Speech (Condition: lowered level; Outcome: improvement; Degree: pronounced; Duration: short-term; Population: ALS patients; Basis: trial)
Affects Conversion: T4 (Product: triiodothyronine)
Antagonizes: Chromium
Antagonizes: Zinc (Frequency: common)
Associated With: Amyotrophic lateral sclerosis (Level: above normal; Location: intracellular)
Associated With: Alzheimer's disease (Level: below normal; Location: intracellular)
Associated With: Arthritis, Immune system dysfunctions, Type II diabetes (Level: high)
Associated With: Garlic breath odor (Level: high; Condition: without_eating_garlic)
Associated With: Cataracts, Immune system dysfunctions, Joint / bone pain (Level: low)
Associated With: Cancers (Level: low; Cancers: lung, skin, prostate, liver, colorectal, breast)
Associated With: Alzheimer's disease (Level: very low; Location: intracellular)
Associates With: Sulfur
Binds: Heavy metals (Quantity: multiple; Toxicity: toxic)
Causes: Bone loss (Condition: needless supplementation or prolonged high level; Mechanism: chromium antagonism)
Causes: Weight loss (Level: low)
Cautioned For: Compromised immune system
Contributes To: Bone loss (Condition: needless_supplementation_or_high_level; Modality: can)
Inhibits: Chromium
Opposes: Chromium
Pairs With: Sulfur
Protects Against: Arsenic, Cadmium, Lead, Mercury
Provokes: Inflammatory response (Condition: excessive uptake or retention; Example: ALS)
Provokes: Degenerative response (Condition: insufficient uptake or retention; Example: Alzheimer's disease)
Provokes: Inflammatory response (Uptake: excessive; Retention: excessive; Example: ALS; Location: central nervous system)
Provokes: Degenerative response (Uptake: insufficient; Retention: insufficient; Example: Alzheimer's disease; Location: central nervous system)
Supports: Rutin uptake
Supports: Human health (Necessity: essential)
Supports: Thyroid functions (Recommendation: check and correct status; Alternative to: vitamin B6 injections)
Supports: Thyroid functions (Recommendation: check_and_correct; Instead of: vitamin_b6_injections)
Treats: Acetaminophen overdose, Acetaminophen overdose / liver damage, Liver damage

-> Selenium

Alzheimer's disease - Affects (Aspect: intake)
Magnesium - Antagonizes
Amyotrophic lateral sclerosis - Associates With (Level: above_normal; Location: cellular)
Crohn's disease - Associates With (Level: above_normal; Location: cellular; Frequency: sometimes)
Excessive zinc intake - Disrupts Balance Of (Timing: eventually)
ALS patients - Has Level (Level: above-normal; Domain: intracellular chemistry)
Alzheimer's disease - Has Level (Level: low; Degree: very; Frequency: not always)
Amyotrophic lateral sclerosis - Involves Storage Of (Amount: excessive; Location: cellular)
Selenium antagonists - Lowers (Basis: trial)
Selenium levels - Measures
Crohn's disease - Requires Reduction Of (Amount: minimum; Frequency: sometimes)
Cellular storage - Stores
Electro-acupuncture therapy - Suppresses (Aspect: activity; Basis: trial; Location: strategic acupuncture points)
Vanadium - Synergizes With
Vitamin D - Synergizes With (Condition: normal levels; Dependency: dose)

Thyroid gland - connections

Thyroid gland ->

Absorbs: Radioactive iodine (Amount: excessive; Condition: after nuclear fallout)
Affect: Cardiac output (Timing: subsequently; Association: iodine)
Affects: Cardiac function
Causes: Right-sided cardiac insufficiency (Level: low; Modality: may; Relation: secondary; Exclusion: heart disease and diseases of heart-supporting organs)
Contains: Tin (Polarity: negative; Scope: every examined victim; Context: accidental deaths)
Control: Right side of cardiac output (Jointly: iodine)
Controls: Right cardiac output (Degree: some)
Distinguishes From: Iodine (Polarity: negative; Comparison: radioactive iodine)
Has Symptom: Asthma, Attention Deficit Hyperactivity Disorder, Brittle hair and nails, Cold hands and feet, Constipation, Depression, Dry skin, Edema, Flatulence, Heart palpitations, Memory problems, Menstrual problems, Mental fatigue, Mood swings, Obesity, Physical fatigue, Post-nasal drip, Premenstrual syndrome, Sleep disturbances, Sweating (Function: diminished; Certainty: potential)
Has Symptom: Sinus infections (Function: diminished; Certainty: potential; Frequency: frequent)
Increases Risk Of: Fibrocystic breast disease, Thyroid cancer (Function: diminished; Degree: greater)
Increases Risk Of: Estrogen-positive cancers (Function: diminished; Degree: greater; Scope: various)
Is Associated With: Depression (Source state: low)
Obtains: Iodine (Frequency: normally; Purpose: produce thyroxine)
Reduces: Libido (Function: diminished; Certainty: potential)
Retains: Radioactive iodine (Amount: excessive; Condition: after nuclear fallout)
Secretes: Calcitonin

-> Thyroid gland

Bismuth, Cobalt, Iron, Lithium, Manganese, Nickel, Potassium, Zinc - Affects (Pathway: direct or indirect)
B vitamins - Affects (Scope: most; Pathway: direct or indirect)
Bromine - Antagonizes (Degree: fairly potent)
Vitamin B6 - Maintains (Activity: normal; Dose: ever-increasing; Condition: body adaptation)
L-tyrosine - Normalizes (Certainty: perhaps; Alternative: iodine supplementation)
Magnesium - Normalizes (Condition: low magnesium; Activity: slightly overactive; Frequency: at times)
Iodine supplementation - Normalizes (Scope: most individuals on hypothyroid medication; Simplicity: simply; Dose: extra; Certainty: could)
Potassium iodide - Protects (Modality: can help; Condition: radiation emergency)
Soy products - Reduces (Frequency: regular; Degree: significant; Effect: depressing; Modality: can; Basis: phytoestrogenic properties)
Potassium iodate, Potassium iodide - Saturates (Amount: enough; Route: oral; Timing: 30 minutes to one day before exposure; Alternative timing: a couple of hours according to some sources)
Iodine - Support
Iodine - Supports
Iodine - Supports (Level: low; Modality: may; Context: low thyroid function)

Scarlet fever - connections

Scarlet fever ->

Is A: Infectious diseases

-> Scarlet fever

Blood Type B, Blood Type O - Increases Susceptibility To (Evidence: scientific research)

Does selenium support thyroid deiodinase during fever stress? Does selenium dependent deiodinase convert T4 to active T3? Does selenium deficiency impair thyroid deiodinase enzymes? Can high fever accelerate body vitamin C consumption? Are sudden-onset fever and chills symptoms of influenza? What primary four element quartet regulates thyroid matrix immunity? Can low selenium status lower thyroid peroxidase activity? What nutrient combination optimizes thyroid function? Can low selenium status impair thyroid hormone conversion? What nutrient deficiency is common in stress hypertension? Does Type A blood show higher serum cortisol under stress? Can selenoprotein S SELENOS regulate ER stress inflammatory response? Can high free radical oxidative stress accelerate MD decay? Can high copper intake exacerbate oxidative stress in MD? Can cocoa catechins protect against oxidative cell damage? Can high iron intake raise oxidative stress and heart risks? Can melatonin administration reduce lung oxidative stress in flu? Can stress deplete adrenal gland vitamin C storage rapidly? Can high iron intake promote oxidative cellular stress? Can high iron intake raise oxidative stress in arteries?

Overview

Loading graph...

Display TOP 100%

Loading full knowledge graph…

Building graph…

Preparing…

Filter by Relationship

Filter by Type

Some information may be incomplete, disputed, or incorrect. Review the supporting sources.