HealthMap

Donepezil - connections

Donepezil ->

• Is A: Cholinesterase inhibitors

Dr. Alois Alzheimer - connections

Dr. Alois Alzheimer ->

• Identified: Alzheimer's disease (Year: 1906)

-> Dr. Alois Alzheimer

• Alzheimer's disease - Named After

Alzheimer's disease - connections

Alzheimer's disease ->

• Affects: Selenium (Aspect: intake)
• Causes: Agitation, Apathy, Confusion, Depression, Fear of nonexistent things, Memory loss, Movement problems, Perception problems, Speech problems (Frequency: generally)
• Depletes: Sulfur (Progression: proportional; Terminal: unmeasurable)
• Diagnosed By Excluding: Dementias (Frequency: usually; Scope: other types)
• Has Form: Early-onset Alzheimer's disease, Late-onset Alzheimer's disease
• Has Level: Sulfur (Level: deficient; Degree: very)
• Has Level: Selenium (Level: low; Degree: very; Frequency: not always)
• Is A: Dementias
• Named After: Dr. Alois Alzheimer
• Occurs As: Early-onset Alzheimer's disease (Sex distribution: almost equally in men and women)
• Requires Increase Of: Sulfur supplements
• Requires Increase Of: Eggs, Garlic, Onions (Richness: sulfur_rich)

-> Alzheimer's disease

• Dietary sulfur, Supplemental sulfur - Adjusted For (Recommendation: should; Manner: accordingly)
• Selenium - Associated With (Level: below normal; Location: intracellular)
• Sulfur levels - Associated With (Level: not measurable; Stage: late; Population: every patient tested)
• Sulfur levels - Associated With (Level: significantly below normal; Stage: early; Population: every patient tested)
• Sulfur levels - Associated With (Level: totally deficient; Stage: late; Population: every patient tested)
• Selenium, Sulfur - Associated With (Level: very low; Location: intracellular)
• Vitamin B6, B12 and folic acid combination - Benefits (Polarity: negative; Evidence: another study; Population: Alzheimer's patients)
• Sulfur-raising therapy - Benefits (Response: positive; Observer: Dr. Ronald Roth; Degree: inversely proportional to disease progression)
• Amyloid infection, Prion infection - Causes
• Glutamate - Causes (Concentration: elevated; Location: extracellular; Certainty: thought)
• Intracellular copper - Causes (Level: high; Partner: sulfur deficiency)
• Neurotransmitters - Causes (State: lack; Certainty: thought)
• Acetylcholine deficiency - Component Of (Importance: key)
• Glutamate-rich food sources - Concerns (Certainty: believed; Agent: some researchers)
• Aluminum - Contributes To (Certainty: maintained; Significance: significant)
• Dementias - Due To (Proportion: up to 70%)
• Antibiotics - Halts (Certainty: may; Condition: if it should happen; Aspect: progression)
• Drugs - Halts (Quantity: some; Certainty: may; Condition: if it should happen; Aspect: progression)
• Dr. Alois Alzheimer - Identified (Year: 1906)
• Advanced glycation end products - Implicated In (Domain: dietary)
• Omega-3 essential fatty acids, Vitamin A, Vitamin C, Vitamin E - Implicated In (State: deficiency; Certainty: possible; Domain: nutritional)
• APOE gene mutation, Alcohol abuse, Apolipoprotein E-4, Depression, Free radical damage, Head trauma, Parkinson's disease - Increases Risk Of
• Electromagnetic exposure - Increases Risk Of (Duration: long-term)
• Brain shrinkage - Increases Risk Of (Importance: major)
• Family history of Alzheimer's disease - Increases Risk Of (Predisposition: inherited; Proportion: 5-10%)
• Mental stimulation - Increases Risk Of (State: lack)
• Herpes simplex - Initiates (Certainty: believed; Evidence: one case)
• Late-onset Alzheimer's disease - Is A (Frequency: most common; Onset: age 60 or older)
• Early-onset Alzheimer's disease - Is A (Onset: before age 60)
• Sulfur supplementation - Prevents (Certainty: potential)
• Aluminum, Copper, Iron, Manganese, Zinc - Promotes (Exposure: above normal)
• High-copper, low-sulfur status - Promotes (Mechanism: biochemical platform)
• Vitamin D - Protects Against (Certainty: under study; Effect: neuroprotective; Goal: slow progression)
• Sulfur supplementation - Reverses (Certainty: potential; Condition: not progressed to substantial brain damage)
• Coconut oil - Reverses (Evidence: one case; Publicity: heavy; Mechanism: antimicrobial effect; Condition: believed herpes simplex-initiated development)
• Antibiotics - Slows (Certainty: under study; Aspect: progression)
• Drugs - Slows (Quantity: some; Certainty: may; Aspect: progression)
• Cholinesterase inhibitors - Treats
• Tacrine - Treats (Frequency: not much; Timing: any longer; Reason: potential liver damage)
• MSM - Treats (Stage: early or moderate; Importance: major turning point; Relation: low sulfur)