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Dr. Ronald Roth Acu-Cell AI

Parathyroid Hormone and Bone Resorption

Direct Action: Parathyroid hormone (PTH) plays a primary role in regulating calcium and phosphorus homeostasis in the blood.
Stimulation of Resorption: When blood calcium levels drop, the parathyroid glands secrete PTH, which stimulates bone resorption to release calcium from the skeleton into the bloodstream.
Cellular Mechanism:
PTH acts primarily on osteoblasts (bone-building cells).
This interaction triggers osteoblasts to release chemical signals that activate osteoclasts (bone-resorbing cells).
Long-term Effects: While intermittent, low doses of PTH can have an anabolic (building) effect on bone, chronic elevation of PTH leads to excessive bone breakdown, potentially weakening the bone structure over time.

AI-generated in the approach of Dr. Ronald Roth. Not his own words.

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Connections

Parathyroid hormones - connections

Parathyroid hormones ->

Affects: Bone remodeling
Affects: Kidney functions (Certainty: can; Purpose: retain more calcium)
Increases: Blood phosphorus levels
Increases: Intestinal calcium absorption (Condition: as needed)
Interacts With: Immune-system proteins
Maintains: Serum calcium (Range: 8.5 to 10.5; Together with: calcitonin)

-> Parathyroid hormones

Parathyroid gland - Secretes

Bone loss - connections

-> Bone loss

Vitamin C - Accelerates (Dose: large; Degree: seriously; Mechanism: reduced calcium)
Magnesium - Associated With (Level: high)
Copper, Potassium, Selenium - Causes (Condition: needless supplementation or prolonged high level; Mechanism: chromium antagonism)
Vanadium - Causes (Condition: needless supplementation or prolonged high level; Mechanism: chromium antagonism; Frequency: rarely)
Magnesium - Causes (Level: excessive; Condition: normal_cellular_calcium)
Osteoclasts - Causes (Mechanism: bone resorption)
Simple carbohydrates - Causes (Mechanism: chromium lowering)
Sugar intake - Causes (Mechanism: chromium lowering; Prominence: major; Recognition: overlooked; Prevalence: Western societies)
Copper, Potassium, Selenium, Vanadium - Contributes To (Condition: needless_supplementation_or_high_level; Modality: can)
Astronauts - Experiences (Rate: about_0.2_percent_per_month; Despite: about_2_hours_daily_workouts)
Soft-tissue calcification - Increases Risk Of
Very high protein intake - Increases Risk Of (Certainty: definite concern)
Kidney diseases, Liver diseases - Increases Risk Of (Condition: Aromasin, Arimidex, or Femara use; Degree: greater; Monitoring: careful)
High-carbohydrate diet - Increases Risk Of (Modal: can; Comparison: similar to high-protein diet)
Sodium/magnesium ratio - Increases Risk Of (State: high sodium and low magnesium)
Osteoporosis - Is A (Progression: progressive)
Vitamin K2 - Prevents (Comparison: more_than_vitamin_d_and_synthetic_estrogen)
Strontium - Prevents (Intake: over_1000_mg_daily; Necessity: required)
Vibration treatment - Prevents (Population: infirm_or_wheelchair_bound_included; Intensity: mild)
Nutritional formulations - Prevents (Role: support)
Serum Vitamin D - Prevents (Threshold: 75_nmol_L_or_higher; Alternate: 30_ng_mL)
Men, Postmenopausal women - Prone To (Age: 75; Degree: equal)
Calcium intake - Protects Against (Level: high; Condition: low_vitamin_d)
Vitamin B5 - Reduces (Condition: elevated_phosphorus)
Chromium - Reduces (Level: higher; Modal: may; Outcome: lower incidence)
Xylitol - Reduces (Modality: helps)
AAACa / AdvaCAL Calcium - Reverses (Evidence: some studies; Modality: capable)
Clay - Treats (Degree: superior)
Strontium - Treats (Intake: over_1000_mg_daily; Necessity: required)
Nutritional formulations - Treats (Role: support)
MSM - Worsens (Amount: high; Condition: low_calcium; Modality: may)

Bone - connections

Bone ->

Contains: Calcium fluoride (Amount: about 4%)
Contains: Zinc (Concentration: larger; Reserve: no)
Supplies: Calcium (Condition: dietary deficiency; Purpose: cover requirements)

-> Bone

Fluoride - Decreases In (Intake: reduced; Duration: long; Timing: subsequently; Measure: concentration)
Silicon - Found In (Concentration: highest; Location: body)
Fluorine - Hardens
Retained fluoride - Incorporates Into (Amount: most)
Calcium - Is Found In (Proportion: almost 98%; Population: average 70 kg adult)
Magnesium - Is Found In (Proportion: part of approximately 65%; Population: average 70 kg adult)

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