HealthMap

EGCG and Tumor Angiogenesis

• Epigallocatechin gallate (EGCG) is the major and most potent catechin found in green tea.
• Direct Inhibition: EGCG directly targets and inhibits several key molecular pathways responsible for tumor angiogenesis, which is the formation of new blood vessels that tumors need to grow and metastasize.
• Vascular Endothelial Growth Factor (VEGF): EGCG significantly downregulates the expression and release of VEGF, a primary signaling protein that stimulates angiogenesis.
• Matrix Metalloproteinases (MMPs): EGCG inhibits the activity of MMPs (specifically MMP-2 and MMP-9), which are enzymes that degrade the extracellular matrix and allow endothelial cells to migrate and form new blood vessels.
• Endothelial Cell Proliferation: EGCG suppresses the proliferation, migration, and survival of vascular endothelial cells, effectively cutting off the tumor's blood and nutrient supply.
• Synergistic Nutritional Approach: For optimal support, EGCG should be viewed as part of a comprehensive nutritional and biochemical strategy rather than an isolated treatment, keeping individual mineral and antioxidant balances in mind.