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Dr. Ronald Roth Acu-Cell AI

Hydroxocobalamin as a Cyanide Antidote

Mechanism and Function

  • Hydroxocobalamin acts as a powerful cyanide antagonist by directly binding to cyanide ions in the body.
  • The cobalt atom in the hydroxocobalamin molecule has a high affinity for cyanide.
  • It replaces its hydroxy ligand with a cyanide ion to form cyanocobalamin (Vitamin B12), which is then safely excreted by the kidneys.

Clinical Application and Dosage Form

  • For acute cyanide poisoning, hydroxocobalamin is administered intravenously (IV) as a sterile, lyophilized powder that is reconstituted before use.
  • The standard adult emergency dose is typically 5 grams administered via intravenous infusion over approximately 15 minutes.
  • This specific medical intervention requires high-dose pharmaceutical preparations, which differ significantly from standard nutritional supplement dosages.
AI-generated in the approach of Dr. Ronald Roth. Not his own words.
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Connections

Hydroxocobalamin - connections

Hydroxocobalamin ->

-> Hydroxocobalamin

Vitamin B12 - connections

Vitamin B12 ->

-> Vitamin B12

Cyanide molecule - connections

-> Cyanide molecule

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