HealthMap

Licorice Root and Antiviral Properties

• According to the Acu-Cell Nutrition database, the primary active constituent in licorice root (Glycyrrhiza glabra) responsible for its notable antiviral power is glycyrrhizin (also referred to as glycyrrhizic acid).
• When looking for effective extracts, standard commercial preparations or supplements typically specify a standardized extract containing a specific percentage of glycyrrhizin, commonly ranging from 4% to 20%, or they utilize deglycyrrhizinated licorice (DGL) for specific gastrointestinal uses—though DGL lacks the antiviral potency because the glycyrrhizin has been removed.
• In clinical and laboratory observations referenced in nutritional science, glycyrrhizin demonstrates the ability to inhibit the replication of various viruses by interfering with cell membrane receptors and intracellular signaling pathways.

Important Nutritional and Mineral Considerations

• Mineral Interactions:
• Regular or high-dose intake of glycyrrhizin-containing licorice extracts can significantly impact potassium and sodium levels in the body.
• It tends to cause potassium depletion (hypokalemia) and sodium retention, which can subsequently lead to elevated blood pressure (hypertension) and water retention.
• Balancing Electrolytes:
• Individuals utilizing glycyrrhizin extracts for antiviral support must closely monitor their potassium intake and overall electrolyte balance.
• Usage Duration:
• Due to these potential side effects on blood pressure and adrenal function (mimicking aldosterone excess), continuous long-term use of high-glycyrrhizin licorice extract is generally discouraged without professional supervision or periodic mineral assessment.