HealthMap

Copper toxicity - connections

Copper toxicity ->

• Associates With: ADD, Arthritis, Behavioral problems, Concentration problems, Depression, Headaches, Hemangiomas, Hyperactivity, Learning disability, Memory problems, Mental problems, Physical and mental fatigue, Postpartum depression, Schizophrenia, Sleep disorders, Spinal, muscle, and joint pain, Vascular degeneration, Weight gain
• Associates With: Mood swings (Possible manifestations: violent, criminal, or psychotic behavior)
• Associates With: Cancers (Scope: several types)
• Associates With: Dementias (Scope: some)
• Causes: Nausea, Vomiting (Frequency: common)
• Increases Risk Of: Infections

-> Copper toxicity

• Ceruloplasmin - Minimizes (Level: sufficient)

Copper - connections

Copper ->

• Antagonizes: Chromium, Sulfur, Zinc
• Antagonizes: Sulfur (Degree: potent; Domain: dietary)
• Associated With: Nausea (Intake: high)
• Associated With: Aneurysms, Apathy, Arthritis, Bleeding gums, Bruising, Cardiovascular disease with artery-wall damage, Cardiovascular disease with coronary artery blockage, Depression, Fatigue, Fibroid tumors, Hyperactivity, Immune system dysfunctions, Insomnia, Joint / bone pain, Learning disability, Memory impairment, Moodiness, Nose bleeds, Periodontal disease, Poor wound healing, Soft-tissue calcification, Yeast infection / Candida vulvovaginitis (Level: high)
• Associated With: Hemangiomas (Level: high; Location: liver)
• Associated With: Cancers (Level: high; Scope: most cancers)
• Associated With: Aneurysms, Arrhythmia, Arthritis, Bruising, Cardiovascular disease with artery-wall damage, Graying hair, Immune system dysfunctions, Insomnia, Joint / bone pain, Menopausal flushing, Nose bleeds, Periodontal disease, Poor wound healing, Yeast infection / Candida vulvovaginitis (Level: low)
• Associated With: Bleeding gums (Level: low; Degree: very)
• Associated With: Allergies (Level: low; Frequency: frequent)
• Associated With: Colon cancer (Level: low; Metastasis condition: must remain low with organ metastasis)
• Associated With: Blepharitis, Conjunctivitis (Level: low; Side: right; Frequency: usually; Severity: worse)
• Associates With: Joint degenerative condition (Level: excessive; Frequency: generally; Scope: many)
• Associates With: Calcium, Potassium (Source level: low; Target level: low; Frequency: frequently)
• Catalyzes: Hemoglobin (Importance: important)
• Causes: Osteoporosis (Certainty: can; Level: high)
• Causes: Osteoporosis (Certainty: can; Level: low)
• Causes: Bone loss (Condition: needless supplementation or prolonged high level; Mechanism: chromium antagonism)
• Causes: Weight gain (Frequency: frequent; Context: supplementation_or_chocolate_content)
• Causes: Excessive blood-thinning (Intake: low)
• Causes: Vascular degeneration (Level: excess; Laterality: right; Certainty: invariably)
• Causes: Joint degeneration (Level: high)
• Causes: Medical symptoms (Level: high; Condition: Vitamin C dose reduced below 5,000–10,000 mg range; Timing: as soon as reduced)
• Causes: Vitamin C deficiency (Level: high; Form: pseudo)
• Causes: Osteoarthritis (Level: high; Frequency: common; Alternative: aggravates; Mechanism: lowered_sulfur)
• Causes: Arteriosclerosis (Level: high; Modal: can)
• Causes: Arteriosclerosis (Level: high; Modality: can)
• Causes: Weight loss (Level: low)
• Causes: Leg bone malformation (State: deficient; Severity: severe; Duration: long-term; Progression: increasing)
• Cautioned For: Compromised immune system
• Component Of: Cytochrome oxidase, Dopamine-beta-hydroxylase, Histaminase, Lysil oxidase, Physiologically important enzymes, Superoxide dismutase, Tyrosinase (Necessity: essential)
• Contributes To: Healthy bones
• Contributes To: Bone loss (Condition: needless_supplementation_or_high_level; Modality: can)
• Contributes To: Spinal degeneration (Level: very high; Certainty: very likely)
• Decreases: Copper bioavailability (Level: high; Modal: can)
• Enables: Angiogenesis (Importance: important)
• Enables: Angiogenesis (Role: important cofactor; Location: tumors)
• Enables Synthesis Of: Norepinephrine (Role: cofactor; Partner: dopamine-beta-hydroxylase)
• Exceeds: Chromium (Frequency: invariably; Degree: much_higher)
• Exceeds: Chromium (Frequency: virtually always; Measure: level)
• Exhibits: Anti-inflammatory properties, Degenerative properties (Level: higher)
• Formed Into: Ceruloplasmin (Location: liver)
• Forms: Copper salts (Condition: reaction with skin fatty acids)
• Harms: Concentration, Memory (Level: elevated; Modal: can; Mechanism: sulfur_inhibition)
• Has: Right-sided cell receptor
• Helps: Iron (Process: hemoglobin formation; Location: bone marrow)
• Improves: Stress-coping ability (Certainty: even; Dosage effect: calming)
• Increases: Vascular degeneration (Level: high; Aspect: risk; Degree: greater)
• Increases: Intracellular calcium (Level: higher; Manner: synergistically)
• Increases: Medical problems (Level: steadily_increasing; Timing: over_time)
• Increases Risk Of: Cancers, Cardiovascular disease, Joint degeneration, Mental health issues
• Increases Risk Of: Tumors (Extent: some; Types: benign and malignant)
• Increases Risk Of: Vascular degeneration (Level: high)
• Increases Risk Of: Colorectal cancer (Level: insufficient; Location: cellular; Modality: more likely)
• Inhibits: Hesperidin (Aspect: action)
• Inhibits: Hesperidin, Vitamin C (Frequency: most common; Potency: potent)
• Inhibits: Chromium, Hesperidin, Molybdenum, Nickel, Sulfur, Vitamin C (Level: overload)
• Inhibits: Flavonoid activity (Level: steadily_increasing)
• Interacts With: Headaches (Level: too high)
• Interferes With: Nickel metabolism, Vitamin C metabolism (Level: very high)
• Is A: Trace elements
• Is A: Sulfur antagonists (Degree: potent; Domain: dietary)
• Is Associated With: Depression (Source state: high)
• Is Associated With: Depression (Source state: low)
• Lowers: Sulfur (Level: high)
• Opposes: Chromium, Sulfur
• Opposes: Vitamin C (Rank: top)
• Opposes: Chromium, Hesperidin, Molybdenum, Nickel, Sulfur, Vitamin C (State: elevated)
• Present In: Tissues (Scope: all)
• Promotes: Alzheimer's disease (Exposure: above normal)
• Promotes: Joint degeneration (Level: elevated; Location: right_body_side; Degree: greater)
• Promotes: Osteoporosis (Level: high; Condition: low_chromium)
• Promotes: Arthritis, Inflammatory diseases (Level: high; Condition: low_chromium; Frequency: frequently)
• Provokes: Inflammatory response (State: deficient)
• Reacts With: Fatty acids in skin (Source: bracelets)
• Reduces: Inflammation, Inflammatory conditions
• Reduces: Osteoporosis (Aspect: risk)
• Reduces: Vitamin C (Level: very high; Outcome: below optimum; Exception: Vitamin C supplementation above 1,000 mg/day or prior copper reduction; Frequency: rarely reach optimum)
• Reduces: Copper bioavailability (Storage: excessive)
• Reduces Absorption Of: Zinc in food (Amount: high; Timing: concurrent)
• Stored In: Liver (Amount: most)
• Supports: Estrogen receptor-positive tumors (Level: higher; Mechanism: angiogenesis; Degree: particularly)
• Supports: Human health (Necessity: essential)
• Supports: Angiogenesis (Necessity: necessary)
• Synergizes With: Calcium, Potassium
• Triggers: Joint degeneration (Level: high; Modality: may)
• Triggers: Blepharitis, Conjunctivitis (State: deficient; Onset: acute; Condition: short course of very high Vitamin C intake)
• Weakens: Trabecular bone (Level: high; Condition: low_chromium)
• Weakens: Blood vessels (Level: low; Certainty: can_be_implicated; Effects: weak_fragile)
• Weakens: Blood vessels (Level: low; Effect: weak; Modality: may)
• Weakens: Blood vessels (Level: low; Modal: may; State: weak_or_fragile)

-> Copper

• Magnesium, Molybdenum, Sulfur, Zinc - Antagonizes
• Chromium - Associated With
• Fibroids, Hemangiomas - Associated With (Level: elevated)
• Benign tumors, Malignant tumors - Associated With (Scope: most_types; Level: elevated)
• Chromium - Associates With
• Chromium - Associates With (Degree: closest)
• Albumin - Carries (Destination: liver)
• Vitamin C - Causes (Dose: 2,000 mg/day; Timing: from an early age; Outcome: deficiency; Severity: severe; Duration: long-term)
• Vitamin C - Causes Deficiency Of (Amount: excessive_or_overdose; Certainty: potential; Timing: eventual; Susceptibility: prone)
• AAACa / AdvaCAL Calcium - Changes (Degree: notable; Timing: after a very short trial)
• Bronze - Contains
• Cocoa - Contains (Amount: considerable)
• Cocoa products, Coffee - Contains (Bioavailability: much_higher; Comparison: higher_level_sources)
• Cola drinks, Liver, Nuts, Processed cocoa products, Shellfish, Soy products, Wheat germ - Contains (Level: high)
• Nuts and seeds - Contains (Level: high; Scope: some)
• Bitter chocolate - Contains (Level: highest)
• Light chocolate, Milk chocolate - Contains (Level: lowest)
• Cocoa - Contains (Level: moderately high)
• Mineral formulations - Contains (Threshold: more than 0.5 mg)
• Glucosamine sulfate, MSM - Counteracts (Condition: successful; Degree: partly; Level: high)
• Vitamin C overdose - Deplete (Frequency: regularly; Progression: gradual; Initial state: higher stores)
• Excessive zinc intake - Disrupts Balance Of (Timing: eventually)
• Copper supplementation - Elevates (Modal: may; Condition: not discontinued or reduced)
• Copper-rich foods - Elevates (Modal: may; Duration: chronic)
• One-sided diets - Elevates (Modal: may; Duration: chronic; Condition: lacks cofactors or copper antagonists)
• Multivitamin/mineral supplement - Excludes (Recommendation: should; Condition: tendency to retain too much copper)
• High-copper, low-sulfur chemical pattern - Has Level (Level: high)
• Chocoholics - Has Level (Level: high_or_excessive; Frequency: most; Basis: highest_chocolate_intake)
• Chromium, Molybdenum, Sulfur, Vitamin C - Increases (Aspect: bioavailability; Intake: greater)
• Copper bracelets - Increases (Condition: copper low; Modal: can)
• Estrogen therapy - Increases (Frequency: sometimes; Condition: hemangioma)
• Nickel - Inhibits
• Molybdenum, Sulfur - Inhibits (Condition: supplementation; Location: humans)
• Sulfur - Inhibits (Process: storage; Generality: general; Effect: positive; Condition: high_copper_common)
• Tin - Is Less Toxic Than (Degree: far)
• Chromium, Glucosamine sulfate, Molybdenum - Lowers
• Copper antagonists, Copper co-factors - Lowers (Amount: excessive; Modal: may)
• Vitamin C - Lowers (Amount: larger; Condition: copper high)
• Vitamin C - Lowers (Dose: a few thousand mg; Condition: copper initially low; Outcome: deficient)
• Avoidance of copper-rich foods - Lowers (Importance: important)
• MSM - Lowers (Importance: main action)
• Vitamin C - Lowers (Initial level: excessively high; Evaluation: ideal remedy)
• Chromium supplementation - Lowers (Timing: initially; Frequency: generally)
• Chromium - Lower Than (Average: true; Frequency: always; Exceptions: virtually none)
• Chromium, Molybdenum, Sulfur, Vitamin C - Normalizes
• Chromium - Normalizes (Priority: first)
• Zinc - Opposes (Strength: weakest; Location: intestinal)
• Chromium - Pairs With
• Glucosamine sulfate, MSM - Reduces (Baseline: elevated; Importance: major)
• Chromium, Molybdenum, Sulfur, Vitamin C - Reduces (Intake: greater)
• Liver, Nuts, Shellfish, Soybeans, Wheat germ - Source Of
• Chocolate, Cocoa products, Coffee, Colas - Source Of (Consumption: common; Characterization: addictive)
• Liver, Nuts, Seafood, Seeds, Shellfish, Soy products - Supplies
• Copper containers - Supplies (Route: cooked or stored food and beverages)
• Copper IUDs - Supplies (Route: non-dietary)
• Beer - Supplies (Source: copper container)
• Tap water - Supplies (Source: copper plumbing)
• Aluminum, Calcium, Potassium - Synergizes With
• Zinc - Threatens (Condition: copper low or potassium and calcium below normal; Amount: high)
• Albumin - Transfers (Location: across gut wall)
• Ceruloplasmin - Transports

Amyotrophic lateral sclerosis - connections

Amyotrophic lateral sclerosis ->

• Affects: Men (Frequency: slightly more often; Comparison: women)
• Affects: Bladder control, Bowel control, Hearing, Sexual function, Sight, Smell, Taste, Thinking ability, Touch (Polarity: unaffected)
• Associates With: Selenium, Sulfur (Level: above_normal; Location: cellular)
• Attacks: Nerve cells (Cell type: motor neurons; Location 1: brain; Location 2: spinal column)
• Causes: Muscle weakness (Course: increasing; Duration: months or years)
• Causes: Inability to control muscle movement (Duration: months or years)
• Impairs: Breathing, Speaking, Swallowing (Duration: months or years)
• Involves: Motor neuron degeneration (Progression: progressive)
• Involves Storage Of: Selenium, Sulfur (Amount: excessive; Location: cellular)
• Presents With: Cellular storage (Degree: excessive)
• Requires Avoidance Of: Eggs, Garlic, Onions (Emphasis: particular)
• Requires Avoidance Of: Selenium supplements, Sulfur supplements (Richness: high)

-> Amyotrophic lateral sclerosis

• Dietary sulfur, Supplemental sulfur - Adjusted For (Recommendation: should; Manner: accordingly)
• Selenium - Associated With (Level: above normal; Location: intracellular)
• Sulfur - Associated With (Level: elevated; Location: intracellular)
• Lithium - Benefits (Evidence: animal models; Certainty: reported)
• Eggs, Garlic, Onions - Causes (Polarity: negative)
• Diet - Causes (Polarity: not)
• Mercury poisoning - Causes (Scope: rare_forms; Certainty: attributable)
• Mercury poisoning - Causes (Scope: some forms; Frequency: rare)
• Minocycline - May Treat (Modality: may; Basis: findings; Novelty: new)
• Neurontin - Prescribed For (Frequency: sometimes)
• Lithium - Stops (Aspect: progression; Evidence: clinical trials; Recency: recent; Certainty: suggested; Modality: may)
• Rilutek - Treats
• Lithium - Treats (Evidence: reported; Model: animal; Benefit: beneficial)