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Dr. Ronald Roth Acu-Cell AI

Nickel-Containing Hydrogenases in Microbes

According to nutritional and biochemical principles emphasized at Acu-Cell, trace minerals like nickel play vital cofactor roles in specialized enzymatic reactions, particularly in microorganisms.

The primary nickel-requiring enzymes in this category are:

[NiFe]-Hydrogenases: The most common class of hydrogenases, responsible for either the oxidation of molecular hydrogen ($H_2$) or the reduction of protons to produce hydrogen gas. They feature a bimetallic active site containing both nickel and iron.
[NiFeSe]-Hydrogenases: A specialized subgroup where a selenium-containing cysteine residue is incorporated into the active site alongside nickel and iron, often enhancing catalytic efficiency in specific anaerobes.
[Ni]-Pure Hydrogenases (rare variants): Certain methanogenic archaea utilize nickel-dependent systems closely tied to energy metabolism and carbon fixation pathways.

Biological Significance

Energy Metabolism: Microbes utilize these nickel enzymes to derive energy from hydrogen gas, particularly in anaerobic environments such as sediments, the rumen of cattle, and the human gut.
Synergism with Other Nutrients: Proper function of these microbial metalloenzymes highlights the critical necessity of trace elements. Just as human enzyme systems require precise balances of minerals (such as zinc, magnesium, and copper), microbial enzyme systems are strictly dependent on the availability of adequate nickel and associated cofactors like iron and selenium.

AI-generated in the approach of Dr. Ronald Roth. Not his own words.

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Connections

Nickel - connections

Nickel ->

Activates: Glucose-utilization enzymes (Certainty: may)
Affects: Left coronary artery
Affects: Adrenals, Thyroid gland (Pathway: direct or indirect)
Affects: Cardiac function (Sequence: subsequently; Pathway: direct or indirect)
Associated With: Chronic sinus headache (Level: considerably below normal; Scope: majority of patients)
Associated With: Angina, Anxiety, Asthma, Diarrhea, Headaches, Hypoglycemia, Nausea, Shortness of breath, Skin rash, Stomach irritation, Vomiting (Level: high)
Associated With: Acne (Level: high; Frequency: frequent)
Associated With: Angina (Level: high; Side: left)
Associated With: Anemia, Asthma, Depression, Fatigue, Hyperglycemia, Liver diseases, Sinus congestion, Type II diabetes (Level: low)
Associates With: Cobalt
Associates With: Vitamin C (Documentation: less)
Benefits: Cirrhosis, Hypoadrenalism (Modality: can)
Causes: Vasoconstriction
Causes: Nickel toxicity (Amount: several grams; Route: ingested; Source: non-dietary; Frequency: usually not otherwise)
Causes: Heart failure (Level: high; Intake multiple: 50000–100000; Reference: daily intake)
Causes: Vasoconstriction (Level: high; Location: left coronary artery)
Causes: Vasodilation (Level: low; Location: left coronary artery)
Constitutes: Albumin, Nickeloplasmin (Location: plasma; Amount: most)
Contributes To: Cell membrane metabolism, Hormone metabolism, Lipid metabolism (Certainty: thought)
Controls: Arterial muscular walls (Documentation: less)
Eliminated Via: Feces (Amount: most)
Eliminated Via: Sweat (Amount: small)
Eliminated Via: Urine (Amount: some)
Increases: Red blood cells, Urinary protein (Level: high)
Increases: Intracellular calcium ratio (Level: low; Timing: eventually)
Increases: Copper bioavailability (Modal: may; Condition: low relative to copper)
Increases: Insulin production (Modality: can)
Increases: Insulin response (Timing: after ingestion)
Inhibits: Calcium, Copper, Manganese, Phytic acid, Sodium, Vitamin E, Zinc
Inhibits: Vitamin E (Condition: excess retention)
Inhibits: Cobalt (Level: higher; Dependency: dose)
Interacts With: DNA, RNA
Links To: Dermatitis, Skin allergies (Context: eyeglass frames, dental materials, and costume jewelry)
Modifies: Coronary arteries (Certainty: can; Properties: vasodilating or vasoconstrictive; Condition: Vitamin C/Vitamin E ratio conflict)
Occurs In: DNA, RNA (Amount: significant)
Pairs With: Cobalt
Reduces: Vitamin C requirements (Amount: small; Degree: considerably; Evidence: some patients)
Reduces: Vitamin C megadoses (Amount: small; Regimen: daily dietary or nutritional; Degree: considerably; Benefit: same)
Reduces: Estrogen, Pulse (Level: high)
Reduces: Adrenal function, Blood pressure, Stomach acid (Level: low)
Reduces: Side effects (Mechanism: reduced Vitamin C requirements; Scope: rest of system)
Resolves: Psychiatric misdiagnosis (Condition: abnormal status corrected; Modality: could)
Synergizes With: Bismuth, Germanium, Iron, Phosphorus, Tin, Vitamin C
Synergizes With: Cobalt (Level: normal; Dependency: dose)

-> Nickel

Dr. Ronald Roth - Assesses (Frequency: every patient consultation)
Cluster headache - Associated With (Level: very high; Pattern: one side-dependent chemistry; Frequency: generally)
Iron-deficiency anemia - Co Occurs With (Frequency: often; Level: low)
Excessive zinc intake - Disrupts Balance Of (Timing: eventually)
Vitamin C, Vitamin E - Imbalances (Condition: unmatched increased intake; Certainty: can)
Vitamin E - Inhibits
Cobalt - Inhibits (Level: higher; Dependency: dose)
Copper - Inhibits (Level: overload)
Copper - Opposes (State: elevated)
Kidneys - Regulates (Process: retention; Process scope: elimination)
Beans, Buckwheat seed, Herring, Lentils, Nuts, Oats, Oysters, Peas, Soybeans, Tea, Unrefined whole grains - Source Of
Cobalt - Synergizes With (Level: normal; Dependency: dose)

Digestive enzyme complex - connections

Digestive enzyme complex ->

Is A: Pancreatic enzymes
Treats: Bloating (Location: below_navel; Targets: lactose_fiber_other_gas_causing_agents)

Enzymes - connections

Enzymes ->

Associated With: Metabolic processes (Variety: various)

-> Enzymes

Zinc - Component Of (Quantity: more than 100)
Calcium - Is Cofactor For (Quantity: a number of)

What nickel requiring enzyme hydrogenase exists in microbes? Does nickel substitute for iron in hydrogenase enzyme active site? Are liquid multi vitamins more prone to microbial growth? Does nickel act as a cofactor for urease enzyme in plants? Does nickel support urease enzyme in Helicobacter Pylori? Does creon pancreatic enzyme replacement aid fat absorption? What molybdenum enzyme mARC reduces N-hydroxylated compounds? Which primary selenium-dependent enzyme neutralizes peroxides? Does zinc supplementation improve SOD1 enzyme stability? What digestive enzyme amylase hydrolyzes starch carbohydrates? Does selenium status govern glutathione peroxidase 1 GPX1? What viral neuraminidase enzyme enables influenza cell release? Can drinking alkaline water lower pancreatic enzyme trigger? Which manganese-requiring enzyme protects mitochondrial DNA? What MAO monoamine oxidase enzyme breaks down central amines? What catalase enzyme uses heme iron to neutralize hydrogen peroxide? Can Helicobacter pylori urease enzyme neutralize gastric acid? Does pepsin enzyme digest dietary protein into peptide chains? Does glutathione peroxidase 4 GPX4 prevent cell ferroptosis? Does Type A blood show higher pancreatic enzyme demand?

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