HealthMap

Prednisone and Mineral Loss

Primary Mineral Deficiency

• Calcium depletion is the most significant concern during long-term prednisone or corticosteroid therapy.
• Prednisone significantly inhibits intestinal calcium absorption while simultaneously increasing urinary calcium excretion.

Secondary Mineral and Electrolyte Impacts

• Potassium levels often drop (hypokalemia), leading to potential muscle weakness and fatigue.
• Sodium and water retention frequently occur, which can contribute to hypertension and edema.
• Magnesium balance can also be negatively affected alongside calcium depletion.

Clinical Considerations

• The accelerated loss of bone-building minerals greatly increases the risk of osteopenia and osteoporosis.
• Nutritional support typically focuses on monitoring and supplementing Calcium, Vitamin D, and Potassium levels under professional guidance.