HealthMap

Nickel - connections

Nickel ->

• Activates: Glucose-utilization enzymes (Certainty: may)
• Affects: Left coronary artery
• Affects: Adrenals, Thyroid gland (Pathway: direct or indirect)
• Affects: Cardiac function (Sequence: subsequently; Pathway: direct or indirect)
• Associated With: Chronic sinus headache (Level: considerably below normal; Scope: majority of patients)
• Associated With: Angina, Anxiety, Asthma, Diarrhea, Headaches, Hypoglycemia, Nausea, Shortness of breath, Skin rash, Stomach irritation, Vomiting (Level: high)
• Associated With: Acne (Level: high; Frequency: frequent)
• Associated With: Angina (Level: high; Side: left)
• Associated With: Anemia, Asthma, Depression, Fatigue, Hyperglycemia, Liver diseases, Sinus congestion, Type II diabetes (Level: low)
• Associates With: Cobalt
• Associates With: Vitamin C (Documentation: less)
• Benefits: Cirrhosis, Hypoadrenalism (Modality: can)
• Causes: Vasoconstriction
• Causes: Nickel toxicity (Amount: several grams; Route: ingested; Source: non-dietary; Frequency: usually not otherwise)
• Causes: Heart failure (Level: high; Intake multiple: 50000–100000; Reference: daily intake)
• Causes: Vasoconstriction (Level: high; Location: left coronary artery)
• Causes: Vasodilation (Level: low; Location: left coronary artery)
• Constitutes: Albumin, Nickeloplasmin (Location: plasma; Amount: most)
• Contributes To: Cell membrane metabolism, Hormone metabolism, Lipid metabolism (Certainty: thought)
• Controls: Arterial muscular walls (Documentation: less)
• Eliminated Via: Feces (Amount: most)
• Eliminated Via: Sweat (Amount: small)
• Eliminated Via: Urine (Amount: some)
• Increases: Red blood cells, Urinary protein (Level: high)
• Increases: Intracellular calcium ratio (Level: low; Timing: eventually)
• Increases: Copper bioavailability (Modal: may; Condition: low relative to copper)
• Increases: Insulin production (Modality: can)
• Increases: Insulin response (Timing: after ingestion)
• Inhibits: Calcium, Copper, Manganese, Phytic acid, Sodium, Vitamin E, Zinc
• Inhibits: Vitamin E (Condition: excess retention)
• Inhibits: Cobalt (Level: higher; Dependency: dose)
• Interacts With: DNA, RNA
• Links To: Dermatitis, Skin allergies (Context: eyeglass frames, dental materials, and costume jewelry)
• Modifies: Coronary arteries (Certainty: can; Properties: vasodilating or vasoconstrictive; Condition: Vitamin C/Vitamin E ratio conflict)
• Occurs In: DNA, RNA (Amount: significant)
• Pairs With: Cobalt
• Reduces: Vitamin C requirements (Amount: small; Degree: considerably; Evidence: some patients)
• Reduces: Vitamin C megadoses (Amount: small; Regimen: daily dietary or nutritional; Degree: considerably; Benefit: same)
• Reduces: Estrogen, Pulse (Level: high)
• Reduces: Adrenal function, Blood pressure, Stomach acid (Level: low)
• Reduces: Side effects (Mechanism: reduced Vitamin C requirements; Scope: rest of system)
• Resolves: Psychiatric misdiagnosis (Condition: abnormal status corrected; Modality: could)
• Synergizes With: Bismuth, Germanium, Iron, Phosphorus, Tin, Vitamin C
• Synergizes With: Cobalt (Level: normal; Dependency: dose)

-> Nickel

• Dr. Ronald Roth - Assesses (Frequency: every patient consultation)
• Cluster headache - Associated With (Level: very high; Pattern: one side-dependent chemistry; Frequency: generally)
• Iron-deficiency anemia - Co Occurs With (Frequency: often; Level: low)
• Excessive zinc intake - Disrupts Balance Of (Timing: eventually)
• Vitamin C, Vitamin E - Imbalances (Condition: unmatched increased intake; Certainty: can)
• Vitamin E - Inhibits
• Cobalt - Inhibits (Level: higher; Dependency: dose)
• Copper - Inhibits (Level: overload)
• Copper - Opposes (State: elevated)
• Kidneys - Regulates (Process: retention; Process scope: elimination)
• Beans, Buckwheat seed, Herring, Lentils, Nuts, Oats, Oysters, Peas, Soybeans, Tea, Unrefined whole grains - Source Of
• Cobalt - Synergizes With (Level: normal; Dependency: dose)

Other minerals and trace elements - connections

-> Other minerals and trace elements

• Dietary or supplemental intake - Increases (Initial state: low values; Limit: up to a certain level; Response: non-linear; Scope: most)

Vitamin C - connections

Vitamin C ->

• Accelerates: Bone loss (Dose: large; Degree: seriously; Mechanism: reduced calcium)
• Affects: Insulin/glucose metabolism
• Affects: Menstrual cycle (Certainty: can; Intake: too much; Aspect: length)
• Affects: Calcium metabolism (Degree: much)
• Affects: Liver glycogen storage (Effect: stabilize or interfere; Condition: hypoglycemic or hyperglycemic disposition)
• Affects: Serum calcium (Polarity: unaffected; Intake: excessive)
• Antagonizes: Zinc (Frequency: common)
• Assists: Calcium absorption
• Associated With: Conjunctivitis (Intake: high; Degree: very)
• Associated With: Chronic sinus headache (Level: considerably below normal; Scope: majority of patients)
• Associated With: Blepharitis, Diarrhea, Gastritis, Headaches, Hypoglycemia, Insomnia, Irritability, Joint pains, Leukopenia, Menopausal flushing, Moodiness, Osteoporosis, Premenstrual syndrome, Weakness, Zollinger-Ellison syndrome (Level: high)
• Associated With: Hypotension (Level: high; Scope: systolic blood pressure)
• Associated With: Stomach acid (Level: high; Target level: high)
• Associated With: Anemia, Aneurysms, Anorexia, Apathy, Arthritis, Asthma, Bleeding gums, Bronchitis, Bruising, Cardiovascular disease with artery-wall damage, Cardiovascular disease with coronary artery blockage, Cataracts, Cellulite, Constipation, Depression, Dermatitis, Dupuytren's contracture, Edema, Episcleritis, Fatigue, Fibroid tumors, Gallstones, Gastrointestinal problems, Gingivitis, Glaucoma, Glucose intolerance, Hemorrhoids, Hives, Immune system dysfunctions, Infertility, Itching, Leukemia, Liver degeneration, Memory impairment, Moodiness, Nausea, Nose bleeds, Periodontal disease, Poor wound healing, Scurvy, Shortness of breath, Soft-tissue calcification, Type II diabetes, Vascular degeneration, Yeast infection / Candida vulvovaginitis (Level: low)
• Associated With: Cancers (Level: low; Cancers: esophageal, stomach, lung, cervical, colorectal, prostate, pancreatic; Condition: H. pylori involvement for pancreatic; Evidence: prostate preliminary or animal data)
• Associated With: Gingivitis (Level: low; Duration: chronic)
• Associated With: Bruising (Level: low; Ease: easy)
• Associated With: Acne, Allergies (Level: low; Frequency: frequent)
• Associated With: Infertility (Level: low; Scope: some; Sex: male)
• Associated With: Hypotension (Level: low; Scope: systolic blood pressure)
• Associated With: Mucus (Level: low; State: excess)
• Associated With: Stomach acid (Level: low; Target level: low)
• Benefits: Arteriosclerosis, Atherosclerosis, Cataracts, Glaucoma
• Benefits: Calcium overload (Amount: larger; Frequency: daily)
• Benefits: Leukemia, Prostatitis (Certainty: likely; Dose: higher)
• Benefits: Left-sided ovarian cysts (Certainty: likely; Dose: higher; Location: left-sided)
• Benefits: Anemia (Certainty: likely; Dose: higher; Scope: some forms)
• Benefits: Type II diabetes (Certainty: may; Dose: larger; Mechanism: greater insulin production)
• Benefits: Congestive liver disease (Dose: higher)
• Benefits: Stomach acid (Dose: higher; Condition: low level from elevated calcium)
• Benefits: Bacterial infections, Fungal diseases, Viral infections (Mechanism: cellular immune functions)
• Benefits: Diabetes (Mechanism: insulin production)
• Benefits: Musculoskeletal degeneration (Mechanism: keeping calcium soluble; Degree: mostly)
• Benefits: Cirrhosis, Hypoadrenalism (Modality: can)
• Benefits: Male infertility (Scope: certain cases)
• Causes: Oxidative damage (Certainty: attributed; Dose: above 500 mg/day)
• Causes: Infections (Certainty: can; Intake: too much)
• Causes: Pseudo-deficiency (Condition: increased intake without matching Vitamin E; Certainty: can)
• Causes: Copper (Dose: 2,000 mg/day; Timing: from an early age; Outcome: deficiency; Severity: severe; Duration: long-term)
• Causes: Depressive mood swings (Dose: higher; Condition: hypoglycemia disposition; Modal: can)
• Causes: Blood sugar changes (Dose: higher; Condition: hypoglycemia disposition; Pattern: erratic; Modal: can)
• Causes: Excessive blood-thinning (Intake: low)
• Causes: Cancers (Polarity: no evidence; Dose: higher; Evidence: epidemiological)
• Causes Deficiency Of: Calcium, Copper, Zinc (Amount: excessive_or_overdose; Certainty: potential; Timing: eventual; Susceptibility: prone)
• Complexed With: Bioflavonoids (Necessity: needs; Amount: adequate)
• Corrects: Leg bone malformation (Action: reduced intake; Level: more reasonable)
• Decreases: Histamine production (Certainty: may; Amount: higher)
• Deplete: Calcium (Dose: very high; Condition: not needed; Timing: eventually; Location: bone stores; Outcome: deficiency)
• Enhances: Iron absorption
• Forms: Collagen, Vitamin C Complex
• Imbalances: Nickel (Condition: unmatched increased intake; Certainty: can)
• Impairs: Calcium uptake (Amount: larger; Condition: low calcium and high stomach acid disposition; Mechanism: too much acid; Certainty: can)
• Impairs: Collagen (Level: low; Process: formation and maintenance)
• Impairs: Hormonal functions (Level: low; Quantity: multiple)
• Implicated In: Alzheimer's disease (State: deficiency; Certainty: possible; Domain: nutritional)
• Increases: Copper bioavailability, Iron absorption
• Increases: Insulin production (Amount: larger; Condition: capable of producing insulin)
• Increases: Calcium (Amount: right; Aspect: bioavailability)
• Increases: Copper (Aspect: bioavailability; Intake: greater)
• Increases: Vitamin E (Aspect: requirements; Condition: Vitamin C intake increased and Vitamin C not truly deficient)
• Increases: Vitamin C benefits (Dose: above RDA/DRI; Certainty: most certainly; Scope: general health)
• Increases: Insulin spikes (Dose: very high; Condition: low sodium; Size: larger)
• Increases: Calcium bioavailability (Intake: higher; Modal: may)
• Increases: Iron absorption (Iron form: vegetable or non-heme; Degree: particularly)
• Increases: Stomach acid, Urination (Level: high)
• Increases: Infections (Level: high; Modality: may; Mechanism: copper deficiency)
• Increases: Infections (Level: low; Frequency: frequent)
• Increases: Intracellular calcium ratio (Level: low; Timing: eventually)
• Increases: Copper bioavailability (Modal: may; Condition: low relative to copper)
• Increases: Insulin production (Modality: can)
• Increases Requirement For: Calcium (Intake: excessive; Modal: may)
• Increases Risk: Calcium loss (Target level: above-normal)
• Increases Risk Of: Cancers (Level: low; Scope: various)
• Inhibits: Helicobacter pylori (Degree: somewhat; Amount: larger; Clinical long term: not proven)
• Inhibits: Vitamin B12 (Dose: large; Certainty: claimed; Theory: possible; Practice: generally absent; Evidence: not confirmed)
• Interacts With: Headaches (Level: too low)
• Irritates: Stomach (Amount: larger; Condition: low calcium and high stomach acid disposition; Sensitivity: sensitive; Certainty: can)
• Isolated From: Lemons (Time: 1932)
• Is A: Calcium cofactors
• Is A: Copper antagonists (Condition: individually indicated)
• Lowers: Manganese (Amount: larger)
• Lowers: Copper (Amount: larger; Condition: copper high)
• Lowers: Zinc (Amount: larger; Condition: zinc high)
• Lowers: Copper (Dose: a few thousand mg; Condition: copper initially low; Outcome: deficient)
• Lowers: Manganese (Dose: high supplemental)
• Lowers: Calcium (Dose: higher; Certainty: possibly; Degree: too much)
• Lowers: Calcium (Dose: large; Degree: significantly; Exception: calcium initially high)
• Lowers: Glycogen stores (Dose: very high; Location: liver; Mechanism: lowered manganese)
• Lowers: Copper, Zinc (Initial level: excessively high; Evaluation: ideal remedy)
• Lowers: Calcium (Intake: excessive; Location: cellular; Outcome: deficient)
• Lowers: Zinc (Mechanism: direct)
• Maintains: Collagen
• Maintains: Blood vessels (State: healthy; Necessity: needed)
• Maintains: Skin elasticity, Skin suppleness (With: sulfur)
• Metabolizes: Folic acid, Tryptophan, Tyrosine
• Normalizes: Copper
• Optimizes: Calcium uptake (Target level: normal; Frequency: generally; Outcome: normal)
• Prevents: Soft-tissue calcification (Amount: larger; Frequency: daily)
• Prevents: Scurvy (Dose: about 10 mg; Necessity: necessary)
• Prevents: Soft-tissue calcification (Mechanism: keeping calcium soluble)
• Prevents: Calcification (Target level: normal; Frequency: usually)
• Provides: Food-like benefits (Condition: complexed_with_adequate_bioflavonoids; Degree: more; Mode: duplicate)
• Reduce: Adrenals (Source state: low; Target state: low; Frequency: common; Cause type: nutritional)
• Reduces: Manganese, Zinc
• Reduces: Allergy potential (Certainty: may; Amount: higher; Mechanism: decreased histamine production)
• Reduces: Estrogen-sensitive cancer, Fibroid tumors (Dose: higher; Aspect: development risk; Condition: congestive liver disease with higher estrogen)
• Reduces: High-estrogenic PMS (Dose: higher; Aspect: symptoms; Condition: congestive liver disease)
• Reduces: Shingles symptoms (Dose: very high; Combination: Vitamin E and Vitamin B12; Timing: earliest onset of attack; Effectiveness: found effective)
• Reduces: Copper (Intake: greater)
• Reduces: Estrogen, Progesterone, Prolactin (Level: high)
• Reduces: Insulin production (Level: low)
• Reduces: Cardiovascular disease (Object: risk; Condition: intake proportionate to Vitamin E; Purpose: maintain normal Vitamin C/Vitamin E ratio; Generality: generally)
• Reduces: Manganese (Selection: patient match)
• Releases: Epinephrine, Norepinephrine
• Slows: Wound healing (Level: low)
• Solubilizes: Calcium
• Stimulates: Adrenal function
• Supports: Iron absorption, Thyroid hormone production
• Supports: Insulin (Dose: high supplemental)
• Supports: Cellular immune functions (Importance: important)
• Supports: Wound healing (Necessity: needed)
• Supports: Copper metabolism (Role: cofactor)
• Synergizes With: Vitamin E (Basis: antioxidant)
• Synergizes With: Vitamin E (Context: antioxidant activity)
• Treats: Airborne allergies (Certainty: can)
• Treats: Conjunctivitis (Certainty: may; Dose: higher; Type: infectious; Context: nutritional treatment)
• Treats: Boils (Dose: high; Modal: may)
• Treats: Viral infections (Effectiveness: one of the most effective)
• Treats: Headaches (Group: A; Context: viral infection; Frequency: usually)
• Treats: Iron-deficiency anemia (Mechanism: increased iron absorption)
• Treats: Cold or flu symptoms (Sufficiency: sufficient; Frequency: every few hours; Timing: at first symptoms; Importance: most important)
• Triggers: Inflammatory conditions (Condition: copper_deficiency; Amount: large; Frequency: rare; Modality: could)
• Worsens: Hypoglycemia (Certainty: can; Amount: large; Degree: further)
• Worsens: Infections, Low-estrogenic PMS (Certainty: can; Intake: too much)
• Worsens: Inflammatory conditions (Condition: copper_deficiency; Amount: large; Frequency: rare; Modality: could; State: existing)
• Worsens: Headaches (Condition: opposite-side viral headache; Frequency: occasionally; Certainty: would)
• Worsens: Benign prostatic hypertrophy, Hemochromatosis (Dose: higher)
• Worsens: Renal failure (Dose: higher; Severity: more serious)
• Worsens: Hypoglycemia (Dose: very high; Condition: low sodium)
• Worsens: Right-sided headache (Example: 2; Condition: left headaches correspond to Group A; Timing: that day)
• Worsens: Prostate bleeding (Level: inadequate; State: chronic)

-> Vitamin C

• Calcium, Magnesium - Antagonizes
• Nickel - Associates With (Documentation: less)
• Animal foods - Contains (Amount: almost none)
• Raw fish - Contains (Amount: enough to prevent deficiency symptoms)
• Breast milk - Contains (Amount: higher; Condition: maternal higher intake)
• Fruits, Vegetables - Contains (Amount: mostly; Concentration: highest when fresh and raw)
• Beans, Seeds, Whole grains - Contains (Amount: very little; Exception: sprouted)
• Vitamin C deficiency - Deficiency Of
• Light - Degrades (Sensitivity: present)
• Stress - Deplete (Duration: prolonged; Location: adrenals)
• Alcohol use, Smoking, Stress - Deplete (Rate: more rapidly)
• Cooking - Destroys (Amount: much; Location: food)
• Excessive zinc intake - Disrupts Balance Of (Timing: eventually)
• Vitamin E - Increases (Aspect: requirements; Condition: Vitamin E intake increased and Vitamin E not truly deficient)
• Sprouting - Increases (Foods: whole grains, seeds, or beans; Aspect: content)
• Vitamin E - Increases Requirement For (Level: high)
• Cobalt - Inhibits
• Vitamin E - Inhibits (Basis: ratio-wise; Basis exclusion: antioxidative properties)
• Copper - Inhibits (Frequency: most common; Potency: potent)
• Copper - Inhibits (Level: overload)
• Calcium ascorbate, Sodium ascorbate - Is A (Acidity: non-acidic)
• Copper - Opposes (Rank: top)
• Copper - Opposes (State: elevated)
• Complexed Vitamin C - Outperforms (Comparison: plain alone; Certainty: evidence)
• Vitamin C overdose - Overdose Of
• Air - Oxidizes (Ease: easily)
• Steaming - Preserves (Food: vegetables; Degree: minimizes loss)
• Most other animals - Produces (Location: liver; Source material: glucose; Amount: much higher than current human dietary intake)
• Adults - Receives (Dose: 500–1,000 mg; Generality: generally)
• Children - Receives (Maximum: one-half adult dose; Basis: age)
• Copper - Reduces (Level: very high; Outcome: below optimum; Exception: Vitamin C supplementation above 1,000 mg/day or prior copper reduction; Frequency: rarely reach optimum)
• Pregnant women - Reduces (Recommendation: advisable; Dose: 250–500 mg/day; Timing: one to two weeks before delivery; Condition: currently taking higher amounts)
• Pregnant women - Reduces (Recommendation: must; Dose: 250–500 mg/day; Timing: at weaning; Condition: higher intake)
• Cooking - Removes (Medium: water; Ease: easily)
• Vitamin C requirements - Requirement For
• Apes, Guinea pigs, Humans - Requires (Source: dietary food; Necessity: must obtain)
• Vitamin C deficiency - Results From (Certainty: may; Duration: long-term; Intake: insufficient; Source: dietary or supplemental)
• Broccoli, Cabbage, Citrus fruit, Currants and other berries, Green peppers, Kale, Potatoes, Rose hips, Spinach, Sweet and hot peppers, Tomatoes, Watercress - Source Of
• Hesperidin, Nickel, Rutin, Vitamin A, Vitamin D - Synergizes With