HealthMap

Merck & Co - connections

Merck & Co ->

• Launches: Fosamax marketing campaign (Timing: after_1995_approval)

-> Merck & Co

• Fosamax class-action lawsuit - Targets (Year: 2007)
• FDA - Warns (Year: 1997; Issue: all_women_develop_osteoporosis_at_menopause)
• FDA - Warns (Year: 2001; Issue: website_overstates_benefits_and_minimizes_risks)

Manganese - connections

Manganese ->

• Activates: Urea-formation enzyme
• Affects: Insulin/glucose metabolism
• Affects: Menstrual cycle (Modal: can; Aspect: duration)
• Affects: Menstrual cycle (Modal: can; Aspect: frequency)
• Affects: Menstrual cycle (Modal: can; Aspect: heaviness)
• Affects: Adrenals, Thyroid gland (Pathway: direct or indirect)
• Affects: Cardiac function (Sequence: subsequently; Pathway: direct or indirect)
• Aids: Glucose metabolism (Mechanism: glycolysis cofactor)
• Assists: Calcium absorption
• Associated With: Bruising, Cardiovascular disease with artery-wall damage, Conjunctivitis, Depression, Dizziness, Episcleritis, Estrogen-sensitive cancer, Fatigue, Fibroid tumors, Flushing, Glucose intolerance, Hyperthermia, Hypertonia, Immune system dysfunctions, Impotence, Infertility, Joint / bone pain, Liver degeneration, Miscarriages, Moodiness, Nausea, Tremors, Type II diabetes, Vision impairment, Zollinger-Ellison syndrome (Level: high)
• Associated With: Cancers (Level: high; Cancers: liver, breast, prostate; Subtype: estrogen receptor-positive)
• Associated With: Amenorrhea (Level: high; Degree: very)
• Associated With: Hemangiomas (Level: high; Location: liver)
• Associated With: Stomach acid (Level: high; Target level: high)
• Associated With: Cholesterol (Level: high; Target level: low)
• Associated With: Joint dislocation (Level: insufficient; Frequency: frequently; Joint: particularly knee)
• Associated With: Amenorrhea, Anemia, Apathy, Asthma, Bruising, Cardiovascular disease with artery-wall damage, Cataracts, Cystitis, Delayed sexual maturity, Depression, Digestive problems, Dizziness, Estrogen receptor-negative cancers, Fatigue, Glucose intolerance, Hypogonadism, Hypotension, Hypothermia, Immune system dysfunctions, Impotence, Infertility, Menopausal flushing, Miscarriages, Moodiness, Nausea, Night sweats, Postpartum depression, Soft-tissue calcification, Sweating, Urinary bladder infection, Vision impairment (Level: low)
• Associated With: Cancers (Level: low; Cancers: right breast, stomach; Subtype: estrogen receptor-negative)
• Associated With: Acne (Level: low; Frequency: frequent)
• Associated With: Myopia (Level: low; Life stage: childhood)
• Associated With: Cholesterol (Level: low; Target level: high)
• Associated With: Stomach acid (Level: low; Target level: low)
• Associated With: Postpartum depression (Level: low; Timing: postpartum)
• Associates With: Iron
• Causes: Parkinsonian syndrome (Level: excessive; Modal: can)
• Causes: Mental change, Violence (Level: high; Modal: can)
• Causes: Schizophrenia-like psychiatric disorder (Level: high; Modal: can; Resemblance: schizophrenia)
• Causes: Calcium loss, Magnesium loss (Level: high; Modality: can)
• Causes: Calcium depletion, Magnesium depletion (Level: high; Timing: subsequently)
• Causes: Weight loss (Level: low)
• Cofactors: Glycolysis (Role: co-factor)
• Controls: Glucose response, Liver glycogen storage
• Controls: Estrogen breakdown (Degree: some; Location: liver)
• Delays: Menopause (Modal: can; Effectiveness: effective; Action: level manipulation)
• Depresses: Thyroid activity (Condition: raised through lithium effect on liver function)
• Exhibits: Pro-inflammatory properties (Level: high)
• Has: Estrogen-like properties (Evidence: proven)
• Hastens: Menopause (Modal: can; Frequency: sometimes; Action: level manipulation)
• Helps: Calcium uptake (Role: co-factor)
• Improves: Liver function (Level: lowered; Function: estrogen regulation)
• Improves: Hyperthyroidism (Scope: most cases; Response: readily; Condition: declining estrogen)
• Increases: Libido (Amount: extra; Modal: may; State: lack; Population: both sexes; Scope: some cases)
• Increases: Stomach acid (Frequency: generally; Exception: not always)
• Increases: Intracellular calcium ratio (Level: low; Timing: eventually)
• Increases Risk: Ligament tear, Tendon tear (Level: high)
• Increases Risk: Calcium loss (Target level: above-normal)
• Inhibits: Calcium, Magnesium
• Interacts With: Headaches (Level: too high or too low)
• Interacts With: B vitamins (Mode: antagonistic)
• Interacts With: B vitamins (Mode: synergistic)
• Is A: Calcium cofactors
• Is Associated With: Depression (Source state: high; Related state: low blood sugar)
• Is Associated With: Depression (Source state: low; Related state: low blood sugar)
• Linked To: Estrogen-sensitive cancer (Level: high)
• Linked To: Estrogen receptor-negative cancers (Level: low)
• Lowers: Iron level (Attribution: some sources; Certainty: claimed; Likelihood: mostly theoretical; Condition: unusual circumstances only)
• Lowers: Total cholesterol (Importance: important)
• Lowers: Calcium (Level: elevated; Condition: some_liver_diseases)
• Lowers: Iron level (Polarity: not observed; Setting: actual clinical; Dose: up to 150 mg per day; Duration: ongoing; Evidence: no single case)
• Maintains: Calcium bioavailability
• Mimics: Estrogen (Property: estrogenic)
• Mimics: Estrogen (Strength: strong)
• Optimizes: Calcium uptake (Target level: normal; Frequency: generally; Outcome: normal)
• Prevents: Iron-manganese ratio conflict (Condition: manganese low; Degree: further)
• Prevents: Calcification (Target level: normal; Frequency: usually)
• Promotes: Alzheimer's disease (Exposure: above normal)
• Provokes: Vascular headache (Level: below normal; Certainty: can)
• Reduces: Iron requirement (Condition: supplemented concurrently; Degree: substantially)
• Reduces: Dopamine (Level: excessive; Location: brain cells; Outcome: Parkinsonian syndrome)
• Reduces: Side effects (Potential: yes; Context: routine iron supplementation)
• Reduces: Potassium (State: elevated)
• Remedy For: Hypoglycemia (Form: chelated; Dose minimum: 25 mg/day; Dose maximum: 50 mg+/day)
• Required For: Blood clotting, DNA synthesis, Gluconeogenesis, RNA synthesis
• Required For: Brain function, Muscle function (State: normal)
• Resolves: Joint dislocation (State: normalized; Permanence: permanently; Condition: insufficient manganese cases)
• Stabilizes: Blood sugar (Effect: helps)
• Stabilizes: Blood sugar (Population: diabetic and hypoglycemic individuals; Importance: important)
• Supports: Human health (Importance: essential)
• Supports: Bone formation, Carbohydrate metabolism, Protein metabolism (Importance: important)
• Supports: Enzyme system (Importance: important; Quantity: many)
• Supports: Iron level (Level: low; Duration: long period; Ease: very easily)
• Supports Synthesis: Cholesterol, L-dopamine
• Treats: Carpal tunnel syndrome, Deafness, Epilepsy, Infertility (Amount: extra; Modal: may; Scope: some cases)
• Treats: Menopausal symptoms (Basis: estrogenic_qualities)
• Treats: Postpartum depression (Combination: Vitamin B1; Effectiveness: most effective)
• Treats: Menopausal symptoms, Menstrual problems, Osteoporosis (Method: nutritional; Importance: most important)
• Treats: Asthma (Modal: can; Scope: some types)
• Treats: Muscle rigidity, Muscle twitching (Modal: may; Condition: Parkinson's disease; Scope: some symptoms)
• Treats: Minor iron deficiency (Scope: most; Method: alone; Iron: without)
• Treats: Hyperthyroidism (Severity: mild; Effect: generally helpful; Condition: individually indicated)
• Triggers: Migraines (Level: elevated; Certainty: can; Type: classic)
• Triggers: Menstrual cycle (Modal: can; Timing: after starting menopause; Recurrence: again)

-> Manganese

• Complex carbohydrates - Affects (Polarity: none)
• Herbal supplement - Affects (Purpose: liver cleanse; Frequency: always; Aspect: status)
• Calcium, Magnesium - Antagonizes
• Iron absorption - Depends On
• Potassium intake - Depletes (Level: high; Timing: gradually; Location: body)
• Congestive liver disease - Implicates (Level: elevated; Certainty: and/or)
• Devil's Claw - Increases (Duration: ongoing; Timing: eventually; Aspect: level)
• Statin drugs - Increases (Frequency: frequently; Aspect: level)
• Congestive liver disease - Increases (Level: high)
• Estrogen - Increases (Level: higher; Location: intracellular)
• Liver chemistry - Increases (Level: higher; Storage: liver; Independence: consumption)
• Proton pump inhibitors - Increases (Mechanism: effect on liver function; Level: excessive)
• Vitamin E - Increases (Process: absorption)
• Boron, Equalized B-Complex, Nickel - Inhibits
• Stomach acid - Interacts With (Mode: synergistic; Degree: heavily)
• Congestive liver disease - Is Associated With (Level: higher; Frequency: generally)
• Boron - Lowers
• Potassium - Lowers (Amount: high)
• Vitamin C - Lowers (Amount: larger)
• Simple carbohydrates - Lowers (Condition: hypoglycemic tendencies)
• Vitamin B6, Vitamin C - Lowers (Dose: high supplemental)
• Boron - Lowers (Tradeoff: calcium and magnesium retention; Evidence: Dr. Ronald Roth's trials)
• Medical situation - Modifies Interaction (Scope: various; Interaction target: B vitamins)
• Iron - Pairs With
• Simple carbohydrates - Raises (Condition: hyperglycemic inclination)
• Lithium - Raises (Tendency: present)
• Extra potassium intake, Vitamin C - Reduces
• Vitamin B6 - Reduces (Caution: required; Selection: patient match)
• Vitamin B6 - Reduces (Level: high; Target state: deficient)
• Calcium, Potassium, Vitamin C - Reduces (Selection: patient match)
• Cobalt, Vitamin A - Synergizes With

Manganese storage - connections

Manganese storage ->

• Predisposes: Tumor development (Level: excessive; Modal: can; Lead time: 10 or 20 years)

-> Manganese storage

• Stomach acid - Associated With (Level: reduced; State: below normal; Timing: after tumor development)
• Tumor development - Associated With (Timing: by tumor development; Location: liver; State: absent or below normal; Frequency: not always)
• Milk thistle - Decreases (Amount: higher; Timing: in time)
• Grapefruit - Increases (Modal: can; Level: higher; Mechanism: altered liver metabolism)
• Medications - Increases (Scope: many; Level: higher; Independence: regardless of consumption)
• Perimenopausal hormone change, Postmenopausal hormone change - Reduces (Modal: may; Level: below normal)