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Dr. Ronald Roth Acu-Cell AI

Selenium Transport and Selenoprotein P

  • Primary role: Yes, Selenoprotein P (SELENOP) functions as a major transporter of selenium in the blood plasma.
  • Hepatic origin: It is synthesized primarily in the liver and subsequently secreted into the circulatory system to distribute selenium to various extrahepatic tissues.
  • Endothelial uptake: Cells take up SELENOP via specific receptor-mediated endocytosis, particularly involving megalin and reelin receptors, ensuring targeted delivery to high-priority organs such as the brain and testes.
  • Functional dualism: In addition to its transport function, SELENOP acts as an extracellular antioxidant, containing multiple selenocysteine residues that neutralize reactive oxygen species in plasma.
AI-generated in the approach of Dr. Ronald Roth. Not his own words.
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Connections

Substance P - connections

Substance P ->

Selenium - connections

Selenium ->

-> Selenium

Plasma estradiol - connections

-> Plasma estradiol

  • Boron - Raises (Attribution: some researchers)
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