HealthMap

Neural tube defects - connections

-> Neural tube defects

• Fetal development - Associated With
• Folic acid - Protects Against (Population: newborns; Dose: up_to_5_mg_per_day; Risk: high; Timing: start_2_to_3_months_before_conception)

Folic acid - connections

Folic acid ->

• Antagonizes: Zinc (Frequency: common)
• Associated With: Cardiovascular disease with coronary artery blockage (Intake: high; Duration: long_term)
• Associated With: Asthma, Kidney damage, Nausea, Pernicious anemia, Respiratory tract infections (Level: high)
• Associated With: Abdominal bloating (Level: high; Alternative: distention)
• Associated With: Appetite (Level: high; Target level: lost)
• Associated With: Cardiovascular disease with artery-wall damage, Cervical dysplasia, Confusion, Depression, Forgetfulness, Hemolytic anemia, Insomnia, Irritability, Leukemia, Megaloblastic anemia, Mental disorders, Pernicious anemia, Vascular degeneration (Level: low)
• Associated With: Fetal development (Level: low; State: abnormal)
• Associated With: Blood pressure (Level: low; Target level: high)
• Associated With: Homocysteine (Level: low; Target level: higher)
• Associated With: Energy (Level: low; Target level: low)
• Benefits: Sodium sensitivity (Certainty: might; Amount: extra)
• Benefits: Hyperadrenalism (Certainty: might; Amount: extra; Predisposition: tendency)
• Causes: Nerve damage (Condition: regular supplementation causing Vitamin B12 deficiency; Modality: potential; Permanence: permanent)
• Causes: Vitamin B12 deficiency (Frequency: regularly; Modality: can)
• Improves: Coronary heart disease (Certainty: conflicting_evidence; Mechanism: homocysteine_reduction)
• Increases: Cholesterol LDL/HDL ratio, Potassium requirements, Zinc requirements (Level: high)
• Increases Risk Of: Cancers (Amount: high; Condition: not_indicated; Scope: some; Combination: vitamin_b12)
• Increases Risk Of: Oral cleft malformations (Level: high)
• Increases Risk Of: Cancers (Level: high; Scope: some; Condition: vitamin_b12_supplementation)
• Increases Risk Of: Cancers (Level: low; Scope: some)
• Interacts With: Vitamin B12
• Interacts With: Headaches (Level: too low)
• Lowers: Sodium
• Lowers: Homocysteine (Ability: able)
• Lowers: Sodium (Amount: higher; Recommendation: should have been supplemented; Condition: toxemia context)
• Lowers: Homocysteine (Location: blood; Dose: less_than_1_mg_per_day_sufficient)
• Masks: Pernicious anemia (Level: high; Modal: may; Cause: vitamin_b12_deficiency)
• More Potent Than: Folate (Degree: about_twice)
• Prevents: Folate deficiency (Certainty: may; Context: vitamin_b12_supplementation)
• Prevents: Red blood cells (Intake: high; Object: Vitamin B12-deficiency changes)
• Prevents: Nerve damage (Polarity: negative; Cause: Vitamin B12 deficiency)
• Protects Against: Birth defects (Certainty: possibly; Population: newborns; Scope: other; Dose: up_to_5_mg_per_day; Risk: high; Timing: start_2_to_3_months_before_conception)
• Protects Against: Neural tube defects (Population: newborns; Dose: up_to_5_mg_per_day; Risk: high; Timing: start_2_to_3_months_before_conception)
• Taken With: Eggs (Timing: morning-afternoon)
• Worsens: Childhood leukemia (Level: high; Scope: some_types)

-> Folic acid

• Vitamin C - Metabolizes
• Intestinal bacteria - Produces
• Vitamin B12 - Requires Supplementation With (Level: high; Duration: long-term; Purpose: prevent listed anemia and sensory symptoms)

Birth defects - connections

Birth defects ->

• Affects: Fetus

-> Birth defects

• Vitamin A - Associated With (Level: high; Threshold: >8,000 IU/day)
• Calcium, Vitamin B12 - Associated With (Level: low)
• Zinc deficiency - Contributes To (Certainty: implicated)
• Fluoride - Increases (Polarity: does not; Level: current; Medium: drinking water; Measure: risk)
• Calcium deficiency - Increases Risk Of (Duration: chronic; Subject: mother; Affected: baby)
• Vitamin A - Induces (Certainty: potential; Dose: greater than 3000 IU/day; Population: females of child-bearing age; Target: fetus)
• Calcium deficiency - Is Associated With (Duration: chronic; Subject: mother; Time: pregnancy; Scope: heart defects in children)
• Folic acid - Protects Against (Certainty: possibly; Population: newborns; Scope: other; Dose: up_to_5_mg_per_day; Risk: high; Timing: start_2_to_3_months_before_conception)